Impact of comorbidities on ischemic stroke outcomes in women

Cheryl D. Bushnell; Jeanne Lee; Pamela W. Duncan; L. Kristin Newby; Larry B. Goldstein

doi:10.1161/STROKEAHA.107.509281

Impact of comorbidities on ischemic stroke outcomes in women

Cheryl D. Bushnell
, Jeanne Lee
, Pamela W. Duncan
, L. Kristin Newby
, Larry B. Goldstein

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

BACKGROUND AND PURPOSE-We assessed the association of prestroke comorbidities with long-term stroke outcomes among women with ischemic stroke. METHODS-Prestroke comorbid conditions in 133 women admitted with acute ischemic stroke were scored with the Charlson Index (CI). We assessed whether the CI and other specific conditions were associated with modified Rankin Score (mRS) at 90 days or more poststroke. RESULTS-After adjustment for initial NIHSS and age, higher CI was the sole factor independently associated with poorer 90 day mRS scores. When CI was excluded, coronary disease and diabetes were independently associated with poorer outcome. CONCLUSION-The extent of comorbidities as assessed by the CI is independently associated with 90-day mRS among women with ischemic stroke, but the individual comorbidities of CHD and DM were each associated with functional outcome.

Original language	English
Pages (from-to)	2138-2140
Number of pages	3
Journal	Stroke
Volume	39
Issue number	7
DOIs	https://doi.org/10.1161/STROKEAHA.107.509281
State	Published - Jul 1 2008

Funding

Funders	Funder number
National Institute of Neurological Disorders and Stroke	K23NS041929

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute stroke
Comorbidities
Outcome
Stroke recovery
Women and minorities

ASJC Scopus subject areas

Clinical Neurology
Cardiology and Cardiovascular Medicine
Advanced and Specialized Nursing

Access to Document

10.1161/STROKEAHA.107.509281

Cite this

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title = "Impact of comorbidities on ischemic stroke outcomes in women",

abstract = "BACKGROUND AND PURPOSE-We assessed the association of prestroke comorbidities with long-term stroke outcomes among women with ischemic stroke. METHODS-Prestroke comorbid conditions in 133 women admitted with acute ischemic stroke were scored with the Charlson Index (CI). We assessed whether the CI and other specific conditions were associated with modified Rankin Score (mRS) at 90 days or more poststroke. RESULTS-After adjustment for initial NIHSS and age, higher CI was the sole factor independently associated with poorer 90 day mRS scores. When CI was excluded, coronary disease and diabetes were independently associated with poorer outcome. CONCLUSION-The extent of comorbidities as assessed by the CI is independently associated with 90-day mRS among women with ischemic stroke, but the individual comorbidities of CHD and DM were each associated with functional outcome.",

keywords = "Acute stroke, Comorbidities, Outcome, Stroke recovery, Women and minorities",

author = "Bushnell, \{Cheryl D.\} and Jeanne Lee and Duncan, \{Pamela W.\} and Newby, \{L. Kristin\} and Goldstein, \{Larry B.\}",

year = "2008",

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doi = "10.1161/STROKEAHA.107.509281",

language = "English",

volume = "39",

pages = "2138--2140",

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}

TY - JOUR

T1 - Impact of comorbidities on ischemic stroke outcomes in women

AU - Bushnell, Cheryl D.

AU - Lee, Jeanne

AU - Duncan, Pamela W.

AU - Newby, L. Kristin

AU - Goldstein, Larry B.

PY - 2008/7/1

Y1 - 2008/7/1

N2 - BACKGROUND AND PURPOSE-We assessed the association of prestroke comorbidities with long-term stroke outcomes among women with ischemic stroke. METHODS-Prestroke comorbid conditions in 133 women admitted with acute ischemic stroke were scored with the Charlson Index (CI). We assessed whether the CI and other specific conditions were associated with modified Rankin Score (mRS) at 90 days or more poststroke. RESULTS-After adjustment for initial NIHSS and age, higher CI was the sole factor independently associated with poorer 90 day mRS scores. When CI was excluded, coronary disease and diabetes were independently associated with poorer outcome. CONCLUSION-The extent of comorbidities as assessed by the CI is independently associated with 90-day mRS among women with ischemic stroke, but the individual comorbidities of CHD and DM were each associated with functional outcome.

AB - BACKGROUND AND PURPOSE-We assessed the association of prestroke comorbidities with long-term stroke outcomes among women with ischemic stroke. METHODS-Prestroke comorbid conditions in 133 women admitted with acute ischemic stroke were scored with the Charlson Index (CI). We assessed whether the CI and other specific conditions were associated with modified Rankin Score (mRS) at 90 days or more poststroke. RESULTS-After adjustment for initial NIHSS and age, higher CI was the sole factor independently associated with poorer 90 day mRS scores. When CI was excluded, coronary disease and diabetes were independently associated with poorer outcome. CONCLUSION-The extent of comorbidities as assessed by the CI is independently associated with 90-day mRS among women with ischemic stroke, but the individual comorbidities of CHD and DM were each associated with functional outcome.

KW - Acute stroke

KW - Comorbidities

KW - Outcome

KW - Stroke recovery

KW - Women and minorities

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UR - https://www.scopus.com/pages/publications/47649090157#tab=citedBy

U2 - 10.1161/STROKEAHA.107.509281

DO - 10.1161/STROKEAHA.107.509281

M3 - Article

C2 - 18451349

AN - SCOPUS:47649090157

SN - 0039-2499

VL - 39

SP - 2138

EP - 2140

JO - Stroke

JF - Stroke

IS - 7

ER -

Impact of comorbidities on ischemic stroke outcomes in women

Abstract

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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