Impact of home visit capacity on genetic association studies of late-onset Alzheimer's disease

David W. Fardo; Laura E. Gibbons; Shubhabrata Mukherjee; M. Maria Glymour; Wayne McCormick; Susan M. McCurry; James D. Bowen; Eric B. Larson; Paul K. Crane

doi:10.1016/j.jalz.2017.01.012

Impact of home visit capacity on genetic association studies of late-onset Alzheimer's disease

David W. Fardo, Laura E. Gibbons, Shubhabrata Mukherjee, M. Maria Glymour, Wayne McCormick, Susan M. McCurry, James D. Bowen, Eric B. Larson, Paul K. Crane

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Introduction Findings for genetic correlates of late-onset Alzheimer's disease (LOAD) in studies that rely solely on clinic visits may differ from those with capacity to follow participants unable to attend clinic visits. Methods We evaluated previously identified LOAD-risk single nucleotide variants in the prospective Adult Changes in Thought study, comparing hazard ratios (HRs) estimated using the full data set of both in-home and clinic visits (n = 1697) to HRs estimated using only data that were obtained from clinic visits (n = 1308). Models were adjusted for age, sex, principal components to account for ancestry, and additional health indicators. Results LOAD associations nominally differed for 4 of 21 variants; CR1 and APOE variants were significant after Bonferroni correction. Discussion Estimates of genetic associations may differ for studies limited to clinic-only designs. Home visit capacity should be explored as a possible source of heterogeneity and potential bias in genetic studies.

Original language	English
Pages (from-to)	933-939
Number of pages	7
Journal	Alzheimer's and Dementia
Volume	13
Issue number	8
DOIs	https://doi.org/10.1016/j.jalz.2017.01.012
State	Published - Aug 2017

Bibliographical note

Publisher Copyright:
© 2017 the Alzheimer's Association

Keywords

Ascertainment bias
Bias
Cohort studies
Genetics
Genome-wide association studies
Genome-wide studies
Home research study visits
Inference
Late-onset Alzheimer's disease
Longitudinal studies
Missing data
Population-based studies
Prospective studies
Research clinic study visits
Selection bias

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jalz.2017.01.012

Cite this

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title = "Impact of home visit capacity on genetic association studies of late-onset Alzheimer's disease",

abstract = "Introduction Findings for genetic correlates of late-onset Alzheimer's disease (LOAD) in studies that rely solely on clinic visits may differ from those with capacity to follow participants unable to attend clinic visits. Methods We evaluated previously identified LOAD-risk single nucleotide variants in the prospective Adult Changes in Thought study, comparing hazard ratios (HRs) estimated using the full data set of both in-home and clinic visits (n = 1697) to HRs estimated using only data that were obtained from clinic visits (n = 1308). Models were adjusted for age, sex, principal components to account for ancestry, and additional health indicators. Results LOAD associations nominally differed for 4 of 21 variants; CR1 and APOE variants were significant after Bonferroni correction. Discussion Estimates of genetic associations may differ for studies limited to clinic-only designs. Home visit capacity should be explored as a possible source of heterogeneity and potential bias in genetic studies.",

keywords = "Ascertainment bias, Bias, Cohort studies, Genetics, Genome-wide association studies, Genome-wide studies, Home research study visits, Inference, Late-onset Alzheimer's disease, Longitudinal studies, Missing data, Population-based studies, Prospective studies, Research clinic study visits, Selection bias",

author = "Fardo, {David W.} and Gibbons, {Laura E.} and Shubhabrata Mukherjee and Glymour, {M. Maria} and Wayne McCormick and McCurry, {Susan M.} and Bowen, {James D.} and Larson, {Eric B.} and Crane, {Paul K.}",

note = "Publisher Copyright: {\textcopyright} 2017 the Alzheimer's Association",

year = "2017",

month = aug,

doi = "10.1016/j.jalz.2017.01.012",

language = "English",

volume = "13",

pages = "933--939",

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AU - Fardo, David W.

AU - Gibbons, Laura E.

AU - Mukherjee, Shubhabrata

AU - Glymour, M. Maria

AU - McCormick, Wayne

AU - McCurry, Susan M.

AU - Bowen, James D.

AU - Larson, Eric B.

AU - Crane, Paul K.

PY - 2017/8

Y1 - 2017/8

N2 - Introduction Findings for genetic correlates of late-onset Alzheimer's disease (LOAD) in studies that rely solely on clinic visits may differ from those with capacity to follow participants unable to attend clinic visits. Methods We evaluated previously identified LOAD-risk single nucleotide variants in the prospective Adult Changes in Thought study, comparing hazard ratios (HRs) estimated using the full data set of both in-home and clinic visits (n = 1697) to HRs estimated using only data that were obtained from clinic visits (n = 1308). Models were adjusted for age, sex, principal components to account for ancestry, and additional health indicators. Results LOAD associations nominally differed for 4 of 21 variants; CR1 and APOE variants were significant after Bonferroni correction. Discussion Estimates of genetic associations may differ for studies limited to clinic-only designs. Home visit capacity should be explored as a possible source of heterogeneity and potential bias in genetic studies.

AB - Introduction Findings for genetic correlates of late-onset Alzheimer's disease (LOAD) in studies that rely solely on clinic visits may differ from those with capacity to follow participants unable to attend clinic visits. Methods We evaluated previously identified LOAD-risk single nucleotide variants in the prospective Adult Changes in Thought study, comparing hazard ratios (HRs) estimated using the full data set of both in-home and clinic visits (n = 1697) to HRs estimated using only data that were obtained from clinic visits (n = 1308). Models were adjusted for age, sex, principal components to account for ancestry, and additional health indicators. Results LOAD associations nominally differed for 4 of 21 variants; CR1 and APOE variants were significant after Bonferroni correction. Discussion Estimates of genetic associations may differ for studies limited to clinic-only designs. Home visit capacity should be explored as a possible source of heterogeneity and potential bias in genetic studies.

KW - Ascertainment bias

KW - Bias

KW - Cohort studies

KW - Genetics

KW - Genome-wide association studies

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KW - Inference

KW - Late-onset Alzheimer's disease

KW - Longitudinal studies

KW - Missing data

KW - Population-based studies

KW - Prospective studies

KW - Research clinic study visits

KW - Selection bias

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Impact of home visit capacity on genetic association studies of late-onset Alzheimer's disease

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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