TY - JOUR
T1 - Impact of sex on response to BCG in non-muscle invasive bladder cancer patients
T2 - a contemporary review from a tertiary care center
AU - Bree, Kelly K.
AU - Hensley, Patrick J.
AU - Brooks, Nathan
AU - Matulay, Justin
AU - Nogueras-Gonzalez, Graciela M.
AU - Navai, Neema
AU - Dinney, Colin P.
AU - Kamat, Ashish M.
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2021/11
Y1 - 2021/11
N2 - Purpose: Female sex has been implicated with higher stage at diagnosis and as a negative prognostic factor amongst patients with non-muscle invasive bladder cancer (NMIBC). Whether this holds true with contemporary management paradigms is unknown. We analyzed a cohort of patients treated with adequate bacillus Calmette–Guerin (BCG) for NMIBC in an effort to identify sex-specific influence on BCG response. Methods: An IRB-approved review of patients with NMIBC treated at our institution with at least ‘adequate BCG’, as defined by the US FDA and EAU, from 2000 to 2018 was performed. Patients were then stratified by sex and response to BCG. Non-parametric tests were used to summarize the data overall and by groups. The Kaplan–Meier product limit method was used to calculate median survival endpoints. Results: Of the 541 patients treated with adequate BCG, 111 (20.5%) were female and 430 (79.5%) were male. Female patients were younger (median 66 vs. 69, p = 0.071), had a lower BMI (median 27.3 vs. 28.8, p = 0.010) and were more likely to have no smoking history (49.5% vs. 27.0%, p < 0.001). Tumor characteristics with respect to stage, size, multifocality, presence of carcinoma in situ, and presence of variant histology were similar between sexes. While rates of recurrence were higher in females than in males this, was not statistically significant (44.1% vs. 34.7%, p = 0.064) and Kaplan–Meier estimates of recurrence-free, progression-free and overall survival demonstrated no significant difference between sexes (p = 0.409, p = 0.253, p = 0.171, respectively). Conclusion: In a contemporary cohort of patients with NMIBC treated with adequate BCG, female sex was not associated with adverse oncologic outcomes.
AB - Purpose: Female sex has been implicated with higher stage at diagnosis and as a negative prognostic factor amongst patients with non-muscle invasive bladder cancer (NMIBC). Whether this holds true with contemporary management paradigms is unknown. We analyzed a cohort of patients treated with adequate bacillus Calmette–Guerin (BCG) for NMIBC in an effort to identify sex-specific influence on BCG response. Methods: An IRB-approved review of patients with NMIBC treated at our institution with at least ‘adequate BCG’, as defined by the US FDA and EAU, from 2000 to 2018 was performed. Patients were then stratified by sex and response to BCG. Non-parametric tests were used to summarize the data overall and by groups. The Kaplan–Meier product limit method was used to calculate median survival endpoints. Results: Of the 541 patients treated with adequate BCG, 111 (20.5%) were female and 430 (79.5%) were male. Female patients were younger (median 66 vs. 69, p = 0.071), had a lower BMI (median 27.3 vs. 28.8, p = 0.010) and were more likely to have no smoking history (49.5% vs. 27.0%, p < 0.001). Tumor characteristics with respect to stage, size, multifocality, presence of carcinoma in situ, and presence of variant histology were similar between sexes. While rates of recurrence were higher in females than in males this, was not statistically significant (44.1% vs. 34.7%, p = 0.064) and Kaplan–Meier estimates of recurrence-free, progression-free and overall survival demonstrated no significant difference between sexes (p = 0.409, p = 0.253, p = 0.171, respectively). Conclusion: In a contemporary cohort of patients with NMIBC treated with adequate BCG, female sex was not associated with adverse oncologic outcomes.
KW - BCG
KW - Bladder cancer
KW - Gender
KW - Non-muscle invasive bladder cancer
UR - http://www.scopus.com/inward/record.url?scp=85107834375&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85107834375&partnerID=8YFLogxK
U2 - 10.1007/s00345-021-03755-w
DO - 10.1007/s00345-021-03755-w
M3 - Article
C2 - 34117914
AN - SCOPUS:85107834375
SN - 0724-4983
VL - 39
SP - 4143
EP - 4149
JO - World Journal of Urology
JF - World Journal of Urology
IS - 11
ER -