Impact of time-varying treatment exposures on the risk of venous thromboembolism in multiple myeloma

Joshua D. Brown, Val R. Adams, Daniela C. Moga

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Multiple myeloma (MM) has one of the highest risks of venous thromboembolism (VTE) of all cancers due to pathologic changes and treatment-related exposures. This study assessed the one-year incidence of VTE in newly diagnosed MM and to determine the baseline and time-varying treatment-related factors associated with VTE risk in a U.S.-based cohort. MM patients were identified and age, gender, and baseline comorbidities were determined. Treatment-related exposures included thalidomide derivatives (IMIDs), proteasome inhibitors, cytotoxic chemotherapy, steroids, erythropoietin-stimulating agents (ESAs), stem cell transplants (SCT), hospitalizations, infection, and central venous catheters (CVC). Multiple statistical models were used including a baseline competing risks model, a time-varying exposure Cox proportional hazard (CPH) model, and a case-time-control analysis. The overall incidence of VTE was 107.2 per 1000 person-years with one-half of the VTEs occurring in the first 90 days. The baseline model showed that increasing age, heart failure, and hypertension were associated with one-year incidence of VTE. MM-specific IMID treatment had lower than expected associations with VTE based on prior literature. Instead, exposure to ESAs, SCT, CVC, and infection had higher associations. Based on these results, VTE risk in MM may be less straightforward than considering only chemotherapy exposures, and other treatment-related exposures should be considered to determine patient risk.

Original languageEnglish
Article number93
JournalHealthcare (Switzerland)
Issue number4
StatePublished - Dec 2016

Bibliographical note

Publisher Copyright:
© 2016 by the authors; licensee MDPI, Basel, Switzerland.


  • Case-time-control study design
  • Competing risks
  • Deep vein thrombosis
  • Multiple myeloma
  • Venous thromboembolism

ASJC Scopus subject areas

  • Health Information Management
  • Health Policy
  • Health Informatics
  • Leadership and Management


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