Grade C periodontitis in young individuals is characterized by severe/rapid periodontal destruction, usually early onset, in systemically healthy individuals. An individual’s host response, triggered by a dysbiotic subgingival biofilm, has been reported as a contributor to the tissue destruction, although mechanisms of this response and contributions to such disease remain poorly understood. Nonsurgical treatment has resulted in positive clinical responses for both localized (now molar-incisor pattern) and generalized forms of grade C periodontitis, especially when adjunctive systemic antibiotics are used. Nonsurgical treatment may also affect host responses, although mechanisms leading to significant changes in this response remain unclear. Significant effects on inflammatory response to antigens/bacteria have been described posttreatment, but evidence for long-term effects remains limited. Nonsurgical treatment in these individuals may also modulate a variety of host markers in serum/plasma and gingival crevicular fluid along with clinical parameter improvements. The impact of other adjuncts to nonsurgical treatment focusing on controlling exacerbated immunoinflammatory responses needs to be further explored in grade C periodontitis in young individuals. Recent evidence suggests that nonsurgical treatment with adjunctive laser therapy may modulate host and microbial responses in those subjects, at least in the short term. Available evidence, while very heterogeneous (including variations in disease definition and study designs), does not provide clear conclusions on this topic yet provides important insights for future studies. In this review, studies within the past decade evaluating the impact of nonsurgical treatment on systemic/local host responses in young individuals with grade C periodontitis, as well as long-term clinical responses posttreatment, will be critically appraised and discussed.
|Number of pages||16|
|Journal||Journal of Dental Research|
|State||Published - May 2023|
Bibliographical noteFunding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The authors acknowledge support from National Institutes of Health/National Institute of Dental and Craniofacial Research (grants R01DE019456 and R90DE22530-4), which funded studies/fellowships (L.S. Branco-de-Almeida and I.M. Velsko) that allowed contribution to be made here. I.M. Velsko was also supported by the Werner Siemens Foundation (“Paleobiotechnology”). I.C.V. de Oliveira was supported by Coordination for the Improvement of Higher Education Personnel (Finance Code 001).
© International Association for Dental Research and American Association for Dental, Oral, and Craniofacial Research 2023.
- aggressive periodontitis
- gingival crevicular fluid
- host microbial interactions
- long-term effects
ASJC Scopus subject areas
- Dentistry (all)