Abstract
Performance of rats on a motor learning paradigm that has been demonstrated to be dependent upon cerebellar norepinephrine (NE) was studied in 20-month-old F344 rats. The behavioral task is identical to that described by Watson and McElligott: Rats are trained on a runaway consisting of aluminum pegs arranged in a regular pattern. Rats receive a water reward at either end of the runaway. Subsequent to training, rats are tested for running times on a runway with irregularly spaced rods. The ability of rats to improve their performance (decrease their running times) on this novel motor task is diminished in young rats that have received 6-hydroxydopamine lesions. Rats at 20 months of age are known to have deficits in cerebellar noradrenergic transmission; thus, the hypothesis to be tested was to determine if aged rats demonstrated performance deficits similar to young rats depleted of central stores of NE. The rate of acquisition of the task was determined by the decrease in running times with successive days of training. The ability of 20-month-old F344 rats to acquire proficiency on the novel motor task was impaired and the rate of acquisition of the novel motor task was not different from the young 6-hydroxydopamine-lesioned rats. In an attempt to distinguish between alterations in motor coordination and motor learning, additional tests of psychomotor performance were assessed for all groups of rats. These tests included a walking on 2.5- and 5-cm rods, speed of running on the motor task, and number and types of mistakes made on the motor learning task. The data indicate that none of the above-mentioned factors correlated with the ability of an individual rat to learn the novel motor task, suggesting age-related motor performance deficits may be separable from motor learning deficits. This data is consistent with our hypothesis that age-related alterations in noradrenergic function may underlie the decline in motor learning.
Original language | English |
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Pages (from-to) | 475-481 |
Number of pages | 7 |
Journal | Neurobiology of Aging |
Volume | 13 |
Issue number | 4 |
DOIs | |
State | Published - 1992 |
Bibliographical note
Funding Information:This work was supported by USPHS Grants AG 04418 (P.B.) and AG 06434 (G.A.G.), the Veterans Administration Medical Research Service (P.B.), and the American Federation for Aging Research (P.B.).
Funding
This work was supported by USPHS Grants AG 04418 (P.B.) and AG 06434 (G.A.G.), the Veterans Administration Medical Research Service (P.B.), and the American Federation for Aging Research (P.B.).
Funders | Funder number |
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Veterans Administration Medical Research Service | |
National Institute on Aging | P01AG004418 |
National Institute on Aging | |
American Federation for Aging Research | |
U.S. Public Health Service | AG 04418, AG 06434 |
U.S. Public Health Service |
Keywords
- Aging
- Cerebellum
- Motor learning
- Norepinephrine
ASJC Scopus subject areas
- General Neuroscience
- Aging
- Clinical Neurology
- Developmental Biology
- Geriatrics and Gerontology