Impaired cyclic AMP generation in outer medullary tubules of gentamicin-treated rats

David Kidwell, Sriram Subramaniam, Cobern Ott, Brian Jackson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We have examined the effects of chronic gentamicin treatment on arginine8-vasopressin (AVP)-dependent cyclic AMP (cAMP) metabolism in rat medullary collecting tubules (oMCT) and medullary thick ascending limbs of Henle's loop (mTALH). Gentamicin attenuated AVP-stimulated cAMP accumulation to a greater extent in the mTALH (Δ -51%) than in the oMCT (Δ -25%). The mechanism of attenuation differed between segments, and could not be attributed to either direct inhibition of adenylate cyclase activity nor direct potentiation of cAMP-phosphodiesterase activity. These data suggest that the gentamicin-induced decrease in renal concentrating ability may be due at least in part to reduced AVP-dependent cAMP accumulation in the oMCT and mTALH.

Original languageEnglish
Pages (from-to)489-492
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number3
StatePublished - Dec 4 1990


  • (thick ascending limb of)
  • 5′-cyclic monophosphate
  • AVP
  • Adenosine 3′
  • Aminogiycosides
  • Collecting tubule
  • Henle's loop
  • [Arg]vasopressin

ASJC Scopus subject areas

  • Pharmacology


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