Impaired monosynaptic potentiation in in vitro hippocampal slices from aged, memory-deficient rats

P. W. Landfield, G. Lynch

Research output: Contribution to journalArticlepeer-review

148 Scopus citations

Abstract

Neurophysiological experiments were conducted in vitro on 400 μ thick transverse hippocampal slices from aged and young rats. These slices exhibit neurophysiological responses similar to those of intact hippocampus. The aged rats have previously been found to exhibit impaired retention. Synaptic responses of the Schaffer collateral system were not found to be different between aged and young slices when elicited by very low frequency (0.3 Hz) electrical stimulation. However, the aged slices exhibited marked deficits in frequency and posttetanic potentiation in response to repetitive stimulation (15 Hz). This deficit was interpreted as resulting from an increased tendency to synaptic depression, rather than from impaired potentiation processes. The possibility of a relationship of these physiological deficits in hippocampal synaptic plasticity to the deficits in behavioral plasticity found in these aged animals is considered.

Original languageEnglish
Pages (from-to)523-533
Number of pages11
JournalJournals of Gerontology
Volume32
Issue number5
DOIs
StatePublished - 1977

ASJC Scopus subject areas

  • Aging

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