Implicaciones clínicas de la edad de inicio del trastorno bipolar I: dos subgrupos con diferente pronóstico

Ana González Pinto; Sara Barbeito; Francisco José Díaz; Patricia Vega; Fernando Mosquera; Purificación López; Susana Alberich; Sonia Ruiz De Azua; Amaia Ugarte; Manuel Martín; José De León

doi:10.1016/S1888-9891(09)70711-6

Implicaciones clínicas de la edad de inicio del trastorno bipolar I: dos subgrupos con diferente pronóstico

Translated title of the contribution: Age at onset in bipolar i disorder: Two may be better than three subgroups

Ana González Pinto, Sara Barbeito, Francisco José Díaz, Patricia Vega, Fernando Mosquera, Purificación López, Susana Alberich, Sonia Ruiz De Azua, Amaia Ugarte, Manuel Martín, José De León

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Introduction and objective:Age at onset in bipolar disorder is related to prognosis and to treatment response. However, it is not clear if there are three or two subgroups in relation to age at onset. The objective of this study is to analyze the number of subgroups in relation to age at the beginning of the disease in a representative sample of bipolar I patients and to compare the subgroups in relation to clinical variables. Method: We included 169 patients diagnosed with bipolar I disorder. Normal mixture analysis was performed. The subgroups of patients formed above were compared regarding clinical characteristics. Patients were followed-up during six years. Results: We found three ages at onset subgroups. The early onset group (18.2 ± 2 years) included 34% of the patients. The second group (26.1 ± 5.5 years) included 44% of the patients. The third group (50.9 ± 9.1 years) included 22% of the patients. Early and intermediate onset groups were not significantly different, and had more family history of affective disorders, more psychotic symptoms, more history of suicide attempts and more history of drug abuse history than the late onset group. Conclusions: Our results suggest that there are three groups of age at onset but early and intermediate groups are similar in relation to clinical variables. The late onset group includes almost a quartile of patients and has different clinical profile.

Translated title of the contribution	Age at onset in bipolar i disorder: Two may be better than three subgroups
Original language	Spanish
Pages (from-to)	29-34
Number of pages	6
Journal	Revista de Psiquiatria y Salud Mental
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/S1888-9891(09)70711-6
State	Published - Mar 2009

Bibliographical note

Funding Information:
Preparation of this report was supported by Health Research Funds from the Spanish Government (FIS: PI052761; PI061416; RD06/0011/0014; FI05/00763, RETICS RD06/0011 (REM-TAP) Network, CIBER CB07/09/0024; EC07/90435; EC07/90666), European Regional Development Funds (FE-DER), and by local grants (200411016; 2006111025; 2007/04 and Caja Vital 2006). Dra. González Pinto has been awarded by a Specific collaborative agreement between Spanish Governement (SCIII) and Basque Government to stabilize and intensify research in the National Health System (Boe n.° 21 de 24 de enero de 2007). The research psychiatric department in Santiago Apóstol Hospital is supported by the Stanley Research Foundation (03-RC-003).

Funding

Preparation of this report was supported by Health Research Funds from the Spanish Government (FIS: PI052761; PI061416; RD06/0011/0014; FI05/00763, RETICS RD06/0011 (REM-TAP) Network, CIBER CB07/09/0024; EC07/90435; EC07/90666), European Regional Development Funds (FE-DER), and by local grants (200411016; 2006111025; 2007/04 and Caja Vital 2006). Dra. González Pinto has been awarded by a Specific collaborative agreement between Spanish Governement (SCIII) and Basque Government to stabilize and intensify research in the National Health System (Boe n.° 21 de 24 de enero de 2007). The research psychiatric department in Santiago Apóstol Hospital is supported by the Stanley Research Foundation (03-RC-003).

Funders	Funder number
Hospital Universitario La Fe	2007/04, 200411016, 2006111025
Stanley Research Foundation	03-RC-003
European Regional Development Fund

Keywords

Age at onset
Bipolar disorder
Family history
Manic depressive illness
Normal distribution

ASJC Scopus subject areas

Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S1888-9891(09)70711-6

Cite this

González Pinto, A., Barbeito, S., José Díaz, F., Vega, P., Mosquera, F., López, P., Alberich, S., Ruiz De Azua, S., Ugarte, A., Martín, M., & De León, J. (2009). Implicaciones clínicas de la edad de inicio del trastorno bipolar I: dos subgrupos con diferente pronóstico. Revista de Psiquiatria y Salud Mental, 2(1), 29-34. https://doi.org/10.1016/S1888-9891(09)70711-6

@article{ba92ebcd75924369b1d93db3841eec39,

title = "Implicaciones cl{\'i}nicas de la edad de inicio del trastorno bipolar I: dos subgrupos con diferente pron{\'o}stico",

abstract = "Introduction and objective:Age at onset in bipolar disorder is related to prognosis and to treatment response. However, it is not clear if there are three or two subgroups in relation to age at onset. The objective of this study is to analyze the number of subgroups in relation to age at the beginning of the disease in a representative sample of bipolar I patients and to compare the subgroups in relation to clinical variables. Method: We included 169 patients diagnosed with bipolar I disorder. Normal mixture analysis was performed. The subgroups of patients formed above were compared regarding clinical characteristics. Patients were followed-up during six years. Results: We found three ages at onset subgroups. The early onset group (18.2 ± 2 years) included 34% of the patients. The second group (26.1 ± 5.5 years) included 44% of the patients. The third group (50.9 ± 9.1 years) included 22% of the patients. Early and intermediate onset groups were not significantly different, and had more family history of affective disorders, more psychotic symptoms, more history of suicide attempts and more history of drug abuse history than the late onset group. Conclusions: Our results suggest that there are three groups of age at onset but early and intermediate groups are similar in relation to clinical variables. The late onset group includes almost a quartile of patients and has different clinical profile.",

keywords = "Age at onset, Bipolar disorder, Family history, Manic depressive illness, Normal distribution",

author = "{Gonz{\'a}lez Pinto}, Ana and Sara Barbeito and {Jos{\'e} D{\'i}az}, Francisco and Patricia Vega and Fernando Mosquera and Purificaci{\'o}n L{\'o}pez and Susana Alberich and {Ruiz De Azua}, Sonia and Amaia Ugarte and Manuel Mart{\'i}n and {De Le{\'o}n}, Jos{\'e}",

note = "Funding Information: Preparation of this report was supported by Health Research Funds from the Spanish Government (FIS: PI052761; PI061416; RD06/0011/0014; FI05/00763, RETICS RD06/0011 (REM-TAP) Network, CIBER CB07/09/0024; EC07/90435; EC07/90666), European Regional Development Funds (FE-DER), and by local grants (200411016; 2006111025; 2007/04 and Caja Vital 2006). Dra. Gonz{\'a}lez Pinto has been awarded by a Specific collaborative agreement between Spanish Governement (SCIII) and Basque Government to stabilize and intensify research in the National Health System (Boe n.° 21 de 24 de enero de 2007). The research psychiatric department in Santiago Ap{\'o}stol Hospital is supported by the Stanley Research Foundation (03-RC-003).",

year = "2009",

month = mar,

doi = "10.1016/S1888-9891(09)70711-6",

language = "Spanish",

volume = "2",

pages = "29--34",

number = "1",

}

González Pinto, A, Barbeito, S, José Díaz, F, Vega, P, Mosquera, F, López, P, Alberich, S, Ruiz De Azua, S, Ugarte, A, Martín, M & De León, J 2009, 'Implicaciones clínicas de la edad de inicio del trastorno bipolar I: dos subgrupos con diferente pronóstico', Revista de Psiquiatria y Salud Mental, vol. 2, no. 1, pp. 29-34. https://doi.org/10.1016/S1888-9891(09)70711-6

TY - JOUR

T1 - Implicaciones clínicas de la edad de inicio del trastorno bipolar I

T2 - dos subgrupos con diferente pronóstico

AU - González Pinto, Ana

AU - Barbeito, Sara

AU - José Díaz, Francisco

AU - Vega, Patricia

AU - Mosquera, Fernando

AU - López, Purificación

AU - Alberich, Susana

AU - Ruiz De Azua, Sonia

AU - Ugarte, Amaia

AU - Martín, Manuel

AU - De León, José

N1 - Funding Information: Preparation of this report was supported by Health Research Funds from the Spanish Government (FIS: PI052761; PI061416; RD06/0011/0014; FI05/00763, RETICS RD06/0011 (REM-TAP) Network, CIBER CB07/09/0024; EC07/90435; EC07/90666), European Regional Development Funds (FE-DER), and by local grants (200411016; 2006111025; 2007/04 and Caja Vital 2006). Dra. González Pinto has been awarded by a Specific collaborative agreement between Spanish Governement (SCIII) and Basque Government to stabilize and intensify research in the National Health System (Boe n.° 21 de 24 de enero de 2007). The research psychiatric department in Santiago Apóstol Hospital is supported by the Stanley Research Foundation (03-RC-003).

PY - 2009/3

Y1 - 2009/3

N2 - Introduction and objective:Age at onset in bipolar disorder is related to prognosis and to treatment response. However, it is not clear if there are three or two subgroups in relation to age at onset. The objective of this study is to analyze the number of subgroups in relation to age at the beginning of the disease in a representative sample of bipolar I patients and to compare the subgroups in relation to clinical variables. Method: We included 169 patients diagnosed with bipolar I disorder. Normal mixture analysis was performed. The subgroups of patients formed above were compared regarding clinical characteristics. Patients were followed-up during six years. Results: We found three ages at onset subgroups. The early onset group (18.2 ± 2 years) included 34% of the patients. The second group (26.1 ± 5.5 years) included 44% of the patients. The third group (50.9 ± 9.1 years) included 22% of the patients. Early and intermediate onset groups were not significantly different, and had more family history of affective disorders, more psychotic symptoms, more history of suicide attempts and more history of drug abuse history than the late onset group. Conclusions: Our results suggest that there are three groups of age at onset but early and intermediate groups are similar in relation to clinical variables. The late onset group includes almost a quartile of patients and has different clinical profile.

AB - Introduction and objective:Age at onset in bipolar disorder is related to prognosis and to treatment response. However, it is not clear if there are three or two subgroups in relation to age at onset. The objective of this study is to analyze the number of subgroups in relation to age at the beginning of the disease in a representative sample of bipolar I patients and to compare the subgroups in relation to clinical variables. Method: We included 169 patients diagnosed with bipolar I disorder. Normal mixture analysis was performed. The subgroups of patients formed above were compared regarding clinical characteristics. Patients were followed-up during six years. Results: We found three ages at onset subgroups. The early onset group (18.2 ± 2 years) included 34% of the patients. The second group (26.1 ± 5.5 years) included 44% of the patients. The third group (50.9 ± 9.1 years) included 22% of the patients. Early and intermediate onset groups were not significantly different, and had more family history of affective disorders, more psychotic symptoms, more history of suicide attempts and more history of drug abuse history than the late onset group. Conclusions: Our results suggest that there are three groups of age at onset but early and intermediate groups are similar in relation to clinical variables. The late onset group includes almost a quartile of patients and has different clinical profile.

KW - Age at onset

KW - Bipolar disorder

KW - Family history

KW - Manic depressive illness

KW - Normal distribution

UR - http://www.scopus.com/inward/record.url?scp=65649124143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65649124143&partnerID=8YFLogxK

U2 - 10.1016/S1888-9891(09)70711-6

DO - 10.1016/S1888-9891(09)70711-6

M3 - Article

C2 - 23034195

AN - SCOPUS:65649124143

SN - 1888-9891

VL - 2

SP - 29

EP - 34

JO - Revista de Psiquiatria y Salud Mental

JF - Revista de Psiquiatria y Salud Mental

IS - 1

ER -

Implicaciones clínicas de la edad de inicio del trastorno bipolar I: dos subgrupos con diferente pronóstico

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this