TY - JOUR
T1 - Implications of prolonged expression of Fos-related antigens
AU - Pennypacker, Keith R.
AU - Hong, Jau S.
AU - McMillian, Michael K.
PY - 1995/9
Y1 - 1995/9
N2 - The AP-1 transcription factors are composed of the Fos and Fos-related antigens as well as Jun and related proteins. These factors have been extensively studied in many diverse paradigms using acute stimuli. Recent attention has focussed on long-term elevation of Fos-related antigens in the CNS, and this is discussed by Keith Pennypacker, Jau-S. Hong and Michael McMillian. Repeated or chronic treatment elevates Fos-related antigen levels for days in many different brain regions. Both direct and indirect stimulation are responsible for the protracted increase in Fos-related antigen-immunoreactive proteins, which may modulate late onset genes involved in neuroplasticity. Understanding the role of these factors in long-lasting or permanent disease states may provide insight into potential therapeutic strategies to treat chronic CNS disorders.
AB - The AP-1 transcription factors are composed of the Fos and Fos-related antigens as well as Jun and related proteins. These factors have been extensively studied in many diverse paradigms using acute stimuli. Recent attention has focussed on long-term elevation of Fos-related antigens in the CNS, and this is discussed by Keith Pennypacker, Jau-S. Hong and Michael McMillian. Repeated or chronic treatment elevates Fos-related antigen levels for days in many different brain regions. Both direct and indirect stimulation are responsible for the protracted increase in Fos-related antigen-immunoreactive proteins, which may modulate late onset genes involved in neuroplasticity. Understanding the role of these factors in long-lasting or permanent disease states may provide insight into potential therapeutic strategies to treat chronic CNS disorders.
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U2 - 10.1016/S0165-6147(00)89061-6
DO - 10.1016/S0165-6147(00)89061-6
M3 - Review article
C2 - 7482997
AN - SCOPUS:0029145716
SN - 0165-6147
VL - 16
SP - 317
EP - 321
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 9
ER -