TY - JOUR
T1 - Improved footprint analysis using video recording to assess functional recovery following injury to the rat sciatic nerve
AU - Walker, Janet L.
AU - Resig, Philip
AU - Guarnieri, Stuart
AU - Sisken, Betty F.
AU - Evans, Joyce M.
PY - 1994
Y1 - 1994
N2 - Footprint analysis is a non-invasive method to quantitate functional recovery after crush injury in the rat sciatic nerve model. Traditional methods of producing the footprints for measurement are limited by inability to reliably produce clear prints when the injury is severe. We describe the use of video technique with image analysis to record and measure these prints. Video had fewer unmeasurable prints than ink. For the 1–5 and 2–4 toe spreads, there was good correlation of video measurements with ink method and better repeatability using video as compared with ink. However, the print length parameter determined by video had poorer repeatability and poorly correlated with that measured by ink. Therefore, calculation of a Sciatic Function Index by video is not appropriate. Since the print length also varies with gait velocity, we believe that a ratio of injured:uninjured hindfoot 1–5 toe spreads as measured by video is a more reliable and repeatable measure of functional recovery in this model.
AB - Footprint analysis is a non-invasive method to quantitate functional recovery after crush injury in the rat sciatic nerve model. Traditional methods of producing the footprints for measurement are limited by inability to reliably produce clear prints when the injury is severe. We describe the use of video technique with image analysis to record and measure these prints. Video had fewer unmeasurable prints than ink. For the 1–5 and 2–4 toe spreads, there was good correlation of video measurements with ink method and better repeatability using video as compared with ink. However, the print length parameter determined by video had poorer repeatability and poorly correlated with that measured by ink. Therefore, calculation of a Sciatic Function Index by video is not appropriate. Since the print length also varies with gait velocity, we believe that a ratio of injured:uninjured hindfoot 1–5 toe spreads as measured by video is a more reliable and repeatable measure of functional recovery in this model.
KW - Axonotmesis
KW - Functional recovery
KW - Nerve injury
KW - Nerve regeneration
KW - Peripheral nerve
UR - http://www.scopus.com/inward/record.url?scp=0028350249&partnerID=8YFLogxK
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U2 - 10.3233/RNN-1994-6303
DO - 10.3233/RNN-1994-6303
M3 - Article
AN - SCOPUS:0028350249
SN - 0922-6028
VL - 6
SP - 189
EP - 193
JO - Restorative Neurology and Neuroscience
JF - Restorative Neurology and Neuroscience
IS - 3
ER -