Improvements in systemic metabolism, anthropometrics, and left ventricular geometry 3 months after bariatric surgery

Joshua G. Leichman, David Aguilar, Terri M. King, Snehal Mehta, Charles Majka, Terry Scarborough, Erik B. Wilson, Heinrich Taegtmeyer

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Background: Several lines of evidence have suggested a link between obesity and heart failure, including chronic inflammation, increased sympathetic tone, and insulin resistance. The goal of this study was to evaluate the changes in systemic metabolism, anthropometrics, and left ventricular (LV) contraction, as well as geometry, in clinically severe obese women after bariatric surgery. Methods: Enrollment was offered consecutively to 22 women with clinically severe obesity. Participants underwent abdominal magnetic resonance imaging to quantify the visceral adipose tissue (VAT) area and tissue Doppler imaging echocardiography to measure the LV contractile function. Fasting blood chemistries were drawn to measure inflammatory markers and to calculate insulin sensitivity. All tests were performed before surgery and 3 months postoperatively. Results: Three months after surgery, a significant increase in insulin sensitivity (mean change ± SEM 34.0 ± 10.4, P <.0001) was present. The VAT area had significantly decreased (-66.1 ± 17.8 cm2, P = .002) and was associated with decreases in body mass index, serum glucose concentrations, and high-sensitivity C-reactive protein levels (r = .61 and P = .005, r = .48 and P = .033, and r = .53 and P = .016, respectively). The LV mass decreased significantly (-3.8 ± 1.7 g/m2.7, P = .037), and this decrease was associated with a decrease in glucose concentration (r = .46, P = .041). The LV systolic and diastolic contractile function were normal at baseline, and no change occurred after surgery. Conclusion: The early phase of weight loss after bariatric surgery produces favorable changes in LV geometry, and these are associated with normalization in the glucose metabolism.

Original languageEnglish
Pages (from-to)592-599
Number of pages8
JournalSurgery for Obesity and Related Diseases
Issue number6
StatePublished - Nov 2006


  • Echocardiograph
  • Insulin resistance
  • Left ventricular hypertrophy
  • Magnetic resonance imaging
  • Obesity

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Improvements in systemic metabolism, anthropometrics, and left ventricular geometry 3 months after bariatric surgery'. Together they form a unique fingerprint.

Cite this