TY - JOUR
T1 - In vitro antianaerobic activity of ertapenem (MK-0826) compared to seven other compounds
AU - Hoellman, D. B.
AU - Kelly, L. M.
AU - Credito, K.
AU - Anthony, L.
AU - Ednie, L. M.
AU - Jacobs, M. R.
AU - Appelbaum, P. C.
PY - 2002
Y1 - 2002
N2 - Ertapenem, imipenem, meropenem, ceftriaxone, piperacillin, piperacillin-tazobactam, clindamycin, and metronidazole were agar dilution MIC tested against 431 anaerobes. Imipenem, meropenem, and ertapenem were the most active β-lactams (MICs at which 50% of the strains are inhibited [MIC50s], 0.125 to 0.25 μg/ml; MIC90s, 1.0 to 2.0 μg/ml). Time-kill studies revealed that ertapenem at two times the MIC was bactericidal for 9 of 10 strains after 48 h. The kinetics for other β-lactams were similar to those of ertapenem.
AB - Ertapenem, imipenem, meropenem, ceftriaxone, piperacillin, piperacillin-tazobactam, clindamycin, and metronidazole were agar dilution MIC tested against 431 anaerobes. Imipenem, meropenem, and ertapenem were the most active β-lactams (MICs at which 50% of the strains are inhibited [MIC50s], 0.125 to 0.25 μg/ml; MIC90s, 1.0 to 2.0 μg/ml). Time-kill studies revealed that ertapenem at two times the MIC was bactericidal for 9 of 10 strains after 48 h. The kinetics for other β-lactams were similar to those of ertapenem.
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U2 - 10.1128/AAC.46.1.220-224.2002
DO - 10.1128/AAC.46.1.220-224.2002
M3 - Article
C2 - 11751138
AN - SCOPUS:0036135390
SN - 0066-4804
VL - 46
SP - 220
EP - 224
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 1
ER -
