In vitro antianaerobic activity of ertapenem (MK-0826) compared to seven other compounds

D. B. Hoellman; L. M. Kelly; K. Credito; L. Anthony; L. M. Ednie; M. R. Jacobs; P. C. Appelbaum

doi:10.1128/AAC.46.1.220-224.2002

In vitro antianaerobic activity of ertapenem (MK-0826) compared to seven other compounds

D. B. Hoellman
, L. M. Kelly
, K. Credito
, L. Anthony
, L. M. Ednie
, M. R. Jacobs
, P. C. Appelbaum

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Ertapenem, imipenem, meropenem, ceftriaxone, piperacillin, piperacillin-tazobactam, clindamycin, and metronidazole were agar dilution MIC tested against 431 anaerobes. Imipenem, meropenem, and ertapenem were the most active β-lactams (MICs at which 50% of the strains are inhibited [MIC₅₀s], 0.125 to 0.25 μg/ml; MIC₉₀s, 1.0 to 2.0 μg/ml). Time-kill studies revealed that ertapenem at two times the MIC was bactericidal for 9 of 10 strains after 48 h. The kinetics for other β-lactams were similar to those of ertapenem.

Original language	English
Pages (from-to)	220-224
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	46
Issue number	1
DOIs	https://doi.org/10.1128/AAC.46.1.220-224.2002
State	Published - 2002

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.46.1.220-224.2002

Cite this

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title = "In vitro antianaerobic activity of ertapenem (MK-0826) compared to seven other compounds",

abstract = "Ertapenem, imipenem, meropenem, ceftriaxone, piperacillin, piperacillin-tazobactam, clindamycin, and metronidazole were agar dilution MIC tested against 431 anaerobes. Imipenem, meropenem, and ertapenem were the most active β-lactams (MICs at which 50\% of the strains are inhibited [MIC50s], 0.125 to 0.25 μg/ml; MIC90s, 1.0 to 2.0 μg/ml). Time-kill studies revealed that ertapenem at two times the MIC was bactericidal for 9 of 10 strains after 48 h. The kinetics for other β-lactams were similar to those of ertapenem.",

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language = "English",

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AU - Hoellman, D. B.

AU - Kelly, L. M.

AU - Credito, K.

AU - Anthony, L.

AU - Ednie, L. M.

AU - Jacobs, M. R.

AU - Appelbaum, P. C.

PY - 2002

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AB - Ertapenem, imipenem, meropenem, ceftriaxone, piperacillin, piperacillin-tazobactam, clindamycin, and metronidazole were agar dilution MIC tested against 431 anaerobes. Imipenem, meropenem, and ertapenem were the most active β-lactams (MICs at which 50% of the strains are inhibited [MIC50s], 0.125 to 0.25 μg/ml; MIC90s, 1.0 to 2.0 μg/ml). Time-kill studies revealed that ertapenem at two times the MIC was bactericidal for 9 of 10 strains after 48 h. The kinetics for other β-lactams were similar to those of ertapenem.

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M3 - Article

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AN - SCOPUS:0036135390

SN - 0066-4804

VL - 46

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EP - 224

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 1

ER -

In vitro antianaerobic activity of ertapenem (MK-0826) compared to seven other compounds

Abstract

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