In vitro degradation of polyanhydride/polyester core-shell double-wall microspheres

Emily J. Pollauf; Cory Berkland; Kyekyoon Kim; Daniel W. Pack

doi:10.1016/j.ijpharm.2005.06.004

In vitro degradation of polyanhydride/polyester core-shell double-wall microspheres

Emily J. Pollauf, Cory Berkland, Kyekyoon Kim, Daniel W. Pack

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Double-wall microspheres (DWMS), comprising distinct polymer core and shell phases, are useful and interesting for controlled-release drug delivery. In particular, the presence of a surface-eroding polymer core may be expected to limit water penetration and, therefore, delay degradation of the core phase and drug release. In this study, solid microspheres and DWMS were fabricated using a surface-eroding polymer (poly[1,6-bis(p-carboxyphenoxy)hexane]; PCPH) and a bulk-eroding polymer (poly(d,l-lactide-co-glycolide); PLG). Erosion of the particles was observed by optical and electron microscopy, while polymer degradation was followed by gel permeation chromatography, during incubation in buffer at 37°C. Degradation and erosion were very different depending on which polymer formed the particle shell. Nevertheless, the relatively thin (∼5 μm) PCPH shells could not prevent water penetration, and the PLG cores completely eroded by 6 weeks of incubation.

Original language	English
Pages (from-to)	294-303
Number of pages	10
Journal	International Journal of Pharmaceutics
Volume	301
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2005.06.004
State	Published - Sep 14 2005

Bibliographical note

Funding Information:
This work was partly supported by NIH grant EB002878. The synthesis of PCPH by Matt Kipper and Balaji Narasimhan at Iowa State University is gratefully acknowledged. Scanning electron microscopy was carried out at the Center for Microanalysis of Materials, University of Illinois at Urbana-Champaign, which is partially supported by the U.S. Department of Energy under grant DEFG02-91-ER45439.

Keywords

Degradation
Double-wall microsphere
Microsphere
Poly(d,l-lactide-co-glycolide)
Polyanhydride

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.ijpharm.2005.06.004

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title = "In vitro degradation of polyanhydride/polyester core-shell double-wall microspheres",

abstract = "Double-wall microspheres (DWMS), comprising distinct polymer core and shell phases, are useful and interesting for controlled-release drug delivery. In particular, the presence of a surface-eroding polymer core may be expected to limit water penetration and, therefore, delay degradation of the core phase and drug release. In this study, solid microspheres and DWMS were fabricated using a surface-eroding polymer (poly[1,6-bis(p-carboxyphenoxy)hexane]; PCPH) and a bulk-eroding polymer (poly(d,l-lactide-co-glycolide); PLG). Erosion of the particles was observed by optical and electron microscopy, while polymer degradation was followed by gel permeation chromatography, during incubation in buffer at 37°C. Degradation and erosion were very different depending on which polymer formed the particle shell. Nevertheless, the relatively thin (∼5 μm) PCPH shells could not prevent water penetration, and the PLG cores completely eroded by 6 weeks of incubation.",

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author = "Pollauf, {Emily J.} and Cory Berkland and Kyekyoon Kim and Pack, {Daniel W.}",

note = "Funding Information: This work was partly supported by NIH grant EB002878. The synthesis of PCPH by Matt Kipper and Balaji Narasimhan at Iowa State University is gratefully acknowledged. Scanning electron microscopy was carried out at the Center for Microanalysis of Materials, University of Illinois at Urbana-Champaign, which is partially supported by the U.S. Department of Energy under grant DEFG02-91-ER45439.",

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N1 - Funding Information: This work was partly supported by NIH grant EB002878. The synthesis of PCPH by Matt Kipper and Balaji Narasimhan at Iowa State University is gratefully acknowledged. Scanning electron microscopy was carried out at the Center for Microanalysis of Materials, University of Illinois at Urbana-Champaign, which is partially supported by the U.S. Department of Energy under grant DEFG02-91-ER45439.

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N2 - Double-wall microspheres (DWMS), comprising distinct polymer core and shell phases, are useful and interesting for controlled-release drug delivery. In particular, the presence of a surface-eroding polymer core may be expected to limit water penetration and, therefore, delay degradation of the core phase and drug release. In this study, solid microspheres and DWMS were fabricated using a surface-eroding polymer (poly[1,6-bis(p-carboxyphenoxy)hexane]; PCPH) and a bulk-eroding polymer (poly(d,l-lactide-co-glycolide); PLG). Erosion of the particles was observed by optical and electron microscopy, while polymer degradation was followed by gel permeation chromatography, during incubation in buffer at 37°C. Degradation and erosion were very different depending on which polymer formed the particle shell. Nevertheless, the relatively thin (∼5 μm) PCPH shells could not prevent water penetration, and the PLG cores completely eroded by 6 weeks of incubation.

AB - Double-wall microspheres (DWMS), comprising distinct polymer core and shell phases, are useful and interesting for controlled-release drug delivery. In particular, the presence of a surface-eroding polymer core may be expected to limit water penetration and, therefore, delay degradation of the core phase and drug release. In this study, solid microspheres and DWMS were fabricated using a surface-eroding polymer (poly[1,6-bis(p-carboxyphenoxy)hexane]; PCPH) and a bulk-eroding polymer (poly(d,l-lactide-co-glycolide); PLG). Erosion of the particles was observed by optical and electron microscopy, while polymer degradation was followed by gel permeation chromatography, during incubation in buffer at 37°C. Degradation and erosion were very different depending on which polymer formed the particle shell. Nevertheless, the relatively thin (∼5 μm) PCPH shells could not prevent water penetration, and the PLG cores completely eroded by 6 weeks of incubation.

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In vitro degradation of polyanhydride/polyester core-shell double-wall microspheres

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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