TY - JOUR
T1 - In vitro rates of oxidation and gluconeogenesis from l(+)- and d(-)lactate in bovine tissues
AU - Harmon, D. L.
AU - Britton, R. A.
AU - Prior, R. L.
PY - 1984
Y1 - 1984
N2 - 1. 1. Slices of bovine kidney cortex, liver, heart and sternomandibularis muscle actively metabolized d- and l-lactate. 2. 2. Rates of d-lactate oxidation were greatest in kidney cortex followed by heart and liver with muscle exhibiting the lowest rates. 3. 3. l-lactate oxidation was greatest in kidney cortex followed by heart with liver and muscle exhibiting similar rates. 4. 4. Rates of oxidation of gluconeogenesis were similar for d- and l-lactate at 0.1 mm lactate but d utilization, as a percent of l, decreased as substrate concentrations increased to 50 mM. 5. 5. Bovine tissues appear to possess significant potential for d(-)lactate utilization. Estimates of this and possible interactions are discussed.
AB - 1. 1. Slices of bovine kidney cortex, liver, heart and sternomandibularis muscle actively metabolized d- and l-lactate. 2. 2. Rates of d-lactate oxidation were greatest in kidney cortex followed by heart and liver with muscle exhibiting the lowest rates. 3. 3. l-lactate oxidation was greatest in kidney cortex followed by heart with liver and muscle exhibiting similar rates. 4. 4. Rates of oxidation of gluconeogenesis were similar for d- and l-lactate at 0.1 mm lactate but d utilization, as a percent of l, decreased as substrate concentrations increased to 50 mM. 5. 5. Bovine tissues appear to possess significant potential for d(-)lactate utilization. Estimates of this and possible interactions are discussed.
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U2 - 10.1016/0305-0491(84)90344-4
DO - 10.1016/0305-0491(84)90344-4
M3 - Article
C2 - 6697693
AN - SCOPUS:0021314328
SN - 0305-0491
VL - 77
SP - 365
EP - 368
JO - Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology
JF - Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology
IS - 2
ER -