In vitro release and in vivo anti-tumor efficacy of doxorubicin from biodegradable temperature-sensitive star-shaped PLGA-PEG block copolymer hydrogel

Su Jeong Lee, Yoonsoo Bae, Kazunori Kataoka, Dukjoon Kim, Doo Sung Lee, Sung Chul Kim

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Doxorubicin (DXR) was loaded into two kinds of thermo-responsive biodegradable star-shaped block copolymer (4arm PLGA-PEG) solutions with different PLGA block lengths under various conditions (drug-concentrations, polymer-concentrations and block compositions). All release profiles of DXR from star-block copolymer hydrogels showed sustained patterns. To assess this polymer as a sustained drug-delivery formulation, in vivo anti-tumor efficacy was examined by using tumor-bearing mice treated with DXR-loaded/ DXR-free hydrogels based on the result of the release study. After 1 month, the mice treated with DXR-loaded S11-C1 and DXR-loaded S9-C1 copolymer solutions had remarkably suppressed tumorvolume compared to that of the mice treated with DXR-free copolymer solution. And DXR-loaded S11 hydrogel showed more significant tumor inhibition due to the different hydrophobicity between S9 and S11 copolymers. In vitro release and in vivo anti-tumor activity studies performed for 1 month revealed the potential of this hydrogel as a sustained and long-term drug delivery carrier.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalPolymer Journal
Volume40
Issue number2
DOIs
StatePublished - 2008

Keywords

  • Anti-tumor efficacy
  • Biopolymers
  • Degradable
  • Hydrogel
  • Temperature-sensitive

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry

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