In vivo antitumor activity of folate-conjugated pH-sensitive polymeric micelles for tumor-targeting cancer therapy

Younsoo Bae; Nobuhiro Nishiyama; Shigeto Fukushima; Kazunori Kataoka

In vivo antitumor activity of folate-conjugated pH-sensitive polymeric micelles for tumor-targeting cancer therapy

Younsoo Bae, Nobuhiro Nishiyama, Shigeto Fukushima, Kazunori Kataoka

Research output: Contribution to conference › Paper › peer-review

1 Scopus citations

Abstract

In vivo antitumor activity of multifunctional folate-conjugated intracellular pH-sensitive polymeric micelles has been evaluated in this study. The micelles were prepared from self-assembling amphiphilic block copolymers, folate-poly(ethylene glycol)-poly (aspartate hydrazone adriamycin) [Fol-PEG-P(Asp-Hyd-ADR)]. By folate conjugation, these micelles became highly effective, which is as effective as free ADR, while its toxicity remained low. Therefore, this approach would provide a safer and more patient-friendly methodology for cancer treatment by tumor-targeting active drug delivery.

Original language	English
Pages	1916
Number of pages	1
State	Published - 2006
Event	55th SPSJ Annual Meeting - Nagoya, Japan Duration: May 24 2006 → May 26 2006

Conference

Conference	55th SPSJ Annual Meeting
Country/Territory	Japan
City	Nagoya
Period	5/24/06 → 5/26/06

Keywords

Active drug delivery system
Folate
Polymeric micelle

ASJC Scopus subject areas

General Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "In vivo antitumor activity of folate-conjugated pH-sensitive polymeric micelles for tumor-targeting cancer therapy",

abstract = "In vivo antitumor activity of multifunctional folate-conjugated intracellular pH-sensitive polymeric micelles has been evaluated in this study. The micelles were prepared from self-assembling amphiphilic block copolymers, folate-poly(ethylene glycol)-poly (aspartate hydrazone adriamycin) [Fol-PEG-P(Asp-Hyd-ADR)]. By folate conjugation, these micelles became highly effective, which is as effective as free ADR, while its toxicity remained low. Therefore, this approach would provide a safer and more patient-friendly methodology for cancer treatment by tumor-targeting active drug delivery.",

keywords = "Active drug delivery system, Folate, Polymeric micelle",

author = "Younsoo Bae and Nobuhiro Nishiyama and Shigeto Fukushima and Kazunori Kataoka",

year = "2006",

language = "English",

pages = "1916",

note = "55th SPSJ Annual Meeting ; Conference date: 24-05-2006 Through 26-05-2006",

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TY - CONF

T1 - In vivo antitumor activity of folate-conjugated pH-sensitive polymeric micelles for tumor-targeting cancer therapy

AU - Bae, Younsoo

AU - Nishiyama, Nobuhiro

AU - Fukushima, Shigeto

AU - Kataoka, Kazunori

PY - 2006

Y1 - 2006

N2 - In vivo antitumor activity of multifunctional folate-conjugated intracellular pH-sensitive polymeric micelles has been evaluated in this study. The micelles were prepared from self-assembling amphiphilic block copolymers, folate-poly(ethylene glycol)-poly (aspartate hydrazone adriamycin) [Fol-PEG-P(Asp-Hyd-ADR)]. By folate conjugation, these micelles became highly effective, which is as effective as free ADR, while its toxicity remained low. Therefore, this approach would provide a safer and more patient-friendly methodology for cancer treatment by tumor-targeting active drug delivery.

AB - In vivo antitumor activity of multifunctional folate-conjugated intracellular pH-sensitive polymeric micelles has been evaluated in this study. The micelles were prepared from self-assembling amphiphilic block copolymers, folate-poly(ethylene glycol)-poly (aspartate hydrazone adriamycin) [Fol-PEG-P(Asp-Hyd-ADR)]. By folate conjugation, these micelles became highly effective, which is as effective as free ADR, while its toxicity remained low. Therefore, this approach would provide a safer and more patient-friendly methodology for cancer treatment by tumor-targeting active drug delivery.

KW - Active drug delivery system

KW - Folate

KW - Polymeric micelle

UR - http://www.scopus.com/inward/record.url?scp=33749841749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749841749&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33749841749

SP - 1916

T2 - 55th SPSJ Annual Meeting

Y2 - 24 May 2006 through 26 May 2006

ER -

In vivo antitumor activity of folate-conjugated pH-sensitive polymeric micelles for tumor-targeting cancer therapy

Abstract

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

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