In vivo antitumor activity of folate-conjugated pH-sensitive polymeric micelles for tumor-targeting cancer therapy

Younsoo Bae, Nobuhiro Nishiyama, Shigeto Fukushima, Kazunori Kataoka

Research output: Contribution to conferencePaperpeer-review

1 Scopus citations

Abstract

In vivo antitumor activity of multifunctional folate-conjugated intracellular pH-sensitive polymeric micelles has been evaluated in this study. The micelles were prepared from self-assembling amphiphilic block copolymers, folate-poly(ethylene glycol)-poly (aspartate hydrazone adriamycin) [Fol-PEG-P(Asp-Hyd-ADR)]. By folate conjugation, these micelles became highly effective, which is as effective as free ADR, while its toxicity remained low. Therefore, this approach would provide a safer and more patient-friendly methodology for cancer treatment by tumor-targeting active drug delivery.

Original languageEnglish
Pages1916
Number of pages1
StatePublished - 2006
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: May 24 2006May 26 2006

Conference

Conference55th SPSJ Annual Meeting
Country/TerritoryJapan
CityNagoya
Period5/24/065/26/06

Keywords

  • Active drug delivery system
  • Folate
  • Polymeric micelle

ASJC Scopus subject areas

  • Engineering (all)

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