In vivo cell death mediated by synthetic ion channels

Bryan A. Smith; Megan M. Daschbach; Seth T. Gammon; Shuzhang Xiao; Sarah E. Chapman; Caroline Hudson; Mark Suckow; David Piwnica-Worms; George W. Gokel; W. Matthew Leevy

doi:10.1039/c1cc12933c

In vivo cell death mediated by synthetic ion channels

Bryan A. Smith, Megan M. Daschbach, Seth T. Gammon, Shuzhang Xiao, Sarah E. Chapman, Caroline Hudson, Mark Suckow, David Piwnica-Worms, George W. Gokel, W. Matthew Leevy

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.

Original language	English
Pages (from-to)	7977-7979
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	28
DOIs	https://doi.org/10.1039/c1cc12933c
State	Published - Jul 28 2011

Funding

Funders	Funder number
National Institute of General Medical Sciences	T32GM075762

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c1cc12933c

Cite this

@article{982a2426859a4feea56152b2ed839855,

title = "In vivo cell death mediated by synthetic ion channels",

abstract = "Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.",

author = "Smith, {Bryan A.} and Daschbach, {Megan M.} and Gammon, {Seth T.} and Shuzhang Xiao and Chapman, {Sarah E.} and Caroline Hudson and Mark Suckow and David Piwnica-Worms and Gokel, {George W.} and Leevy, {W. Matthew}",

year = "2011",

month = jul,

day = "28",

doi = "10.1039/c1cc12933c",

language = "English",

volume = "47",

pages = "7977--7979",

number = "28",

}

TY - JOUR

T1 - In vivo cell death mediated by synthetic ion channels

AU - Smith, Bryan A.

AU - Daschbach, Megan M.

AU - Gammon, Seth T.

AU - Xiao, Shuzhang

AU - Chapman, Sarah E.

AU - Hudson, Caroline

AU - Suckow, Mark

AU - Piwnica-Worms, David

AU - Gokel, George W.

AU - Leevy, W. Matthew

PY - 2011/7/28

Y1 - 2011/7/28

N2 - Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.

AB - Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.

UR - http://www.scopus.com/inward/record.url?scp=79959873907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959873907&partnerID=8YFLogxK

U2 - 10.1039/c1cc12933c

DO - 10.1039/c1cc12933c

M3 - Article

C2 - 21681307

AN - SCOPUS:79959873907

SN - 1359-7345

VL - 47

SP - 7977

EP - 7979

JO - Chemical Communications

JF - Chemical Communications

IS - 28

ER -

In vivo cell death mediated by synthetic ion channels

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this