Abstract
Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.
Original language | English |
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Pages (from-to) | 1552-1554 |
Number of pages | 3 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 50 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2006 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases