In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis

Barbara J. Hoeben; David S. Burgess; Jason T. McConville; Laura K. Najvar; Robert L. Talbert; Jay I. Peters; Nathan P. Wiederhold; Bradi L. Frei; John R. Graybill; Rosie Bocanegra; Kirk A. Overhoff; Prapasri Sinswat; Keith P. Johnston; Robert O. Williams

doi:10.1128/AAC.50.4.1552-1554.2006

In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis

Barbara J. Hoeben, David S. Burgess, Jason T. McConville, Laura K. Najvar, Robert L. Talbert, Jay I. Peters, Nathan P. Wiederhold, Bradi L. Frei, John R. Graybill, Rosie Bocanegra, Kirk A. Overhoff, Prapasri Sinswat, Keith P. Johnston, Robert O. Williams

Pharmacy Practice and Science

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.

Original language	English
Pages (from-to)	1552-1554
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	50
Issue number	4
DOIs	https://doi.org/10.1128/AAC.50.4.1552-1554.2006
State	Published - Apr 2006

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.50.4.1552-1554.2006

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Hoeben, B. J., Burgess, D. S., McConville, J. T., Najvar, L. K., Talbert, R. L., Peters, J. I., Wiederhold, N. P., Frei, B. L., Graybill, J. R., Bocanegra, R., Overhoff, K. A., Sinswat, P., Johnston, K. P., & Williams, R. O. (2006). In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis. Antimicrobial Agents and Chemotherapy, 50(4), 1552-1554. https://doi.org/10.1128/AAC.50.4.1552-1554.2006

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title = "In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis",

abstract = "Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.",

author = "Hoeben, {Barbara J.} and Burgess, {David S.} and McConville, {Jason T.} and Najvar, {Laura K.} and Talbert, {Robert L.} and Peters, {Jay I.} and Wiederhold, {Nathan P.} and Frei, {Bradi L.} and Graybill, {John R.} and Rosie Bocanegra and Overhoff, {Kirk A.} and Prapasri Sinswat and Johnston, {Keith P.} and Williams, {Robert O.}",

year = "2006",

month = apr,

doi = "10.1128/AAC.50.4.1552-1554.2006",

language = "English",

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pages = "1552--1554",

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Hoeben, BJ, Burgess, DS, McConville, JT, Najvar, LK, Talbert, RL, Peters, JI, Wiederhold, NP, Frei, BL, Graybill, JR, Bocanegra, R, Overhoff, KA, Sinswat, P, Johnston, KP & Williams, RO 2006, 'In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis', Antimicrobial Agents and Chemotherapy, vol. 50, no. 4, pp. 1552-1554. https://doi.org/10.1128/AAC.50.4.1552-1554.2006

TY - JOUR

T1 - In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis

AU - Hoeben, Barbara J.

AU - Burgess, David S.

AU - McConville, Jason T.

AU - Najvar, Laura K.

AU - Talbert, Robert L.

AU - Peters, Jay I.

AU - Wiederhold, Nathan P.

AU - Frei, Bradi L.

AU - Graybill, John R.

AU - Bocanegra, Rosie

AU - Overhoff, Kirk A.

AU - Sinswat, Prapasri

AU - Johnston, Keith P.

AU - Williams, Robert O.

PY - 2006/4

Y1 - 2006/4

N2 - Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.

AB - Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.

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U2 - 10.1128/AAC.50.4.1552-1554.2006

DO - 10.1128/AAC.50.4.1552-1554.2006

M3 - Article

C2 - 16569882

AN - SCOPUS:33645792333

SN - 0066-4804

VL - 50

SP - 1552

EP - 1554

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 4

ER -

In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis

Abstract

ASJC Scopus subject areas

UN SDGs

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