In vivo light scattering measurements for detection of precancerous conditions of the cervix

Judith R. Mourant; Thérese J. Bocklage; Tamara M. Powers; Heather M. Greene; Kathy L. Bullock; Lisa R. Marr-Lyon; Maxine H. Dorin; Alan G. Waxman; Meggan M. Zsemlye; Harriet O. Smith

doi:10.1016/j.ygyno.2007.01.001

In vivo light scattering measurements for detection of precancerous conditions of the cervix

Judith R. Mourant
, Thérese J. Bocklage
, Tamara M. Powers
, Heather M. Greene
, Kathy L. Bullock
, Lisa R. Marr-Lyon
, Maxine H. Dorin
, Alan G. Waxman
, Meggan M. Zsemlye
, Harriet O. Smith

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Objective.: To examine the utility of in vivo elastic light scattering measurements to diagnose high grade squamous interepithelial lesions (HSIL) of the cervix. Methods.: A newly developed fiber optic probe was used to measure light transport in the cervical epithelium of 36 patients undergoing standard colposcopy. Both unpolarized and polarized light transport were measured in the visible and near-infrared. Spectroscopic results of 29 patients were compared with histopathology of the measured sites using ROC curves, MANOVA and logistic regression. Results.: Three spectroscopic parameters are statistically different for HSIL compared with low-grade lesions and normal tissue. When these three spectroscopic parameters are combined, retrospective sensitivities and specificities for HSIL versus non-HSIL are 100% and 80%, respectively. Conclusions.: Reflectance measurements of elastically scattered light show promise as a non-invasive, real-time method to discriminate HSIL from other abnormalities and normal tissue. These results compare favorably with those obtained by fluorescence alone and by fluorescence combined with light scattering.

Original language	English
Pages (from-to)	439-445
Number of pages	7
Journal	Gynecologic Oncology
Volume	105
Issue number	2
DOIs	https://doi.org/10.1016/j.ygyno.2007.01.001
State	Published - May 2007

Funding

This work was funded by NIH grant CA71898 as well as by the UNM Cancer Treatment Center supported by NCI P30 CA118110. We would like to thank Dr. James P. Freyer for useful discussions and Betty Aranda for doing a few of the spectroscopic measurements.

Funders	Funder number
UNM Cancer Treatment Center
National Institutes of Health (NIH)
National Childhood Cancer Registry – National Cancer Institute	R01CA071898, P30 CA118110

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cervical cancer
Light scattering
Squamous intraepithelial lesions

ASJC Scopus subject areas

Oncology
Obstetrics and Gynecology

Access to Document

10.1016/j.ygyno.2007.01.001

Cite this

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title = "In vivo light scattering measurements for detection of precancerous conditions of the cervix",

abstract = "Objective.: To examine the utility of in vivo elastic light scattering measurements to diagnose high grade squamous interepithelial lesions (HSIL) of the cervix. Methods.: A newly developed fiber optic probe was used to measure light transport in the cervical epithelium of 36 patients undergoing standard colposcopy. Both unpolarized and polarized light transport were measured in the visible and near-infrared. Spectroscopic results of 29 patients were compared with histopathology of the measured sites using ROC curves, MANOVA and logistic regression. Results.: Three spectroscopic parameters are statistically different for HSIL compared with low-grade lesions and normal tissue. When these three spectroscopic parameters are combined, retrospective sensitivities and specificities for HSIL versus non-HSIL are 100\% and 80\%, respectively. Conclusions.: Reflectance measurements of elastically scattered light show promise as a non-invasive, real-time method to discriminate HSIL from other abnormalities and normal tissue. These results compare favorably with those obtained by fluorescence alone and by fluorescence combined with light scattering.",

keywords = "Cervical cancer, Light scattering, Squamous intraepithelial lesions",

author = "Mourant, \{Judith R.\} and Bocklage, \{Th{\'e}rese J.\} and Powers, \{Tamara M.\} and Greene, \{Heather M.\} and Bullock, \{Kathy L.\} and Marr-Lyon, \{Lisa R.\} and Dorin, \{Maxine H.\} and Waxman, \{Alan G.\} and Zsemlye, \{Meggan M.\} and Smith, \{Harriet O.\}",

year = "2007",

month = may,

doi = "10.1016/j.ygyno.2007.01.001",

language = "English",

volume = "105",

pages = "439--445",

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TY - JOUR

T1 - In vivo light scattering measurements for detection of precancerous conditions of the cervix

AU - Mourant, Judith R.

AU - Bocklage, Thérese J.

AU - Powers, Tamara M.

AU - Greene, Heather M.

AU - Bullock, Kathy L.

AU - Marr-Lyon, Lisa R.

AU - Dorin, Maxine H.

AU - Waxman, Alan G.

AU - Zsemlye, Meggan M.

AU - Smith, Harriet O.

PY - 2007/5

Y1 - 2007/5

N2 - Objective.: To examine the utility of in vivo elastic light scattering measurements to diagnose high grade squamous interepithelial lesions (HSIL) of the cervix. Methods.: A newly developed fiber optic probe was used to measure light transport in the cervical epithelium of 36 patients undergoing standard colposcopy. Both unpolarized and polarized light transport were measured in the visible and near-infrared. Spectroscopic results of 29 patients were compared with histopathology of the measured sites using ROC curves, MANOVA and logistic regression. Results.: Three spectroscopic parameters are statistically different for HSIL compared with low-grade lesions and normal tissue. When these three spectroscopic parameters are combined, retrospective sensitivities and specificities for HSIL versus non-HSIL are 100% and 80%, respectively. Conclusions.: Reflectance measurements of elastically scattered light show promise as a non-invasive, real-time method to discriminate HSIL from other abnormalities and normal tissue. These results compare favorably with those obtained by fluorescence alone and by fluorescence combined with light scattering.

AB - Objective.: To examine the utility of in vivo elastic light scattering measurements to diagnose high grade squamous interepithelial lesions (HSIL) of the cervix. Methods.: A newly developed fiber optic probe was used to measure light transport in the cervical epithelium of 36 patients undergoing standard colposcopy. Both unpolarized and polarized light transport were measured in the visible and near-infrared. Spectroscopic results of 29 patients were compared with histopathology of the measured sites using ROC curves, MANOVA and logistic regression. Results.: Three spectroscopic parameters are statistically different for HSIL compared with low-grade lesions and normal tissue. When these three spectroscopic parameters are combined, retrospective sensitivities and specificities for HSIL versus non-HSIL are 100% and 80%, respectively. Conclusions.: Reflectance measurements of elastically scattered light show promise as a non-invasive, real-time method to discriminate HSIL from other abnormalities and normal tissue. These results compare favorably with those obtained by fluorescence alone and by fluorescence combined with light scattering.

KW - Cervical cancer

KW - Light scattering

KW - Squamous intraepithelial lesions

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In vivo light scattering measurements for detection of precancerous conditions of the cervix

Abstract

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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