In vivo magnetic resonance detecting by using tumor-targeted polymeric micelle encapsulated iron hydroxide colloids

Michiaki Kumagai; Yutaka Imai; Youn Soo Bae; Yuichi Yamasaki; Masaki Sekino; Shoogo Ueno; Eiji Kaneko; Kentaro Shimokado; Kazunori Kataoka

In vivo magnetic resonance detecting by using tumor-targeted polymeric micelle encapsulated iron hydroxide colloids

Michiaki Kumagai, Yutaka Imai, Youn Soo Bae, Yuichi Yamasaki, Masaki Sekino, Shoogo Ueno, Eiji Kaneko, Kentaro Shimokado, Kazunori Kataoka

Research output: Contribution to conference › Paper › peer-review

Abstract

We have reported the poly(ethylene glycol) - poly(amino acid) block copolymer micelles encapsulating β-FcOOH nanoparticles as tumor-targeted contrast agent for magnetic resonance imaging(MRI). PEG-PAsp molecules are multi-valently bound to the surface of the iron oxide nanoparticles via coordination between the carboxylic acid from the PAsp segment of block copolymer and Fe on the surface of iron hydroxide nanoparticles. Hence the resultant nanoparticles possess excellent solubility and stability in aqueous solution as well as in physiological saline.

Original language	English
Pages	1986
Number of pages	1
State	Published - 2006
Event	55th SPSJ Annual Meeting - Nagoya, Japan Duration: May 24 2006 → May 26 2006

Conference

Conference	55th SPSJ Annual Meeting
Country/Territory	Japan
City	Nagoya
Period	5/24/06 → 5/26/06

Keywords

Contrast agent
MRI
Polymeric micelle
β-FeOOH

ASJC Scopus subject areas

General Engineering

Cite this

@conference{5731807dcec14090809bc51195549297,

title = "In vivo magnetic resonance detecting by using tumor-targeted polymeric micelle encapsulated iron hydroxide colloids",

abstract = "We have reported the poly(ethylene glycol) - poly(amino acid) block copolymer micelles encapsulating β-FcOOH nanoparticles as tumor-targeted contrast agent for magnetic resonance imaging(MRI). PEG-PAsp molecules are multi-valently bound to the surface of the iron oxide nanoparticles via coordination between the carboxylic acid from the PAsp segment of block copolymer and Fe on the surface of iron hydroxide nanoparticles. Hence the resultant nanoparticles possess excellent solubility and stability in aqueous solution as well as in physiological saline.",

keywords = "Contrast agent, MRI, Polymeric micelle, β-FeOOH",

author = "Michiaki Kumagai and Yutaka Imai and Bae, {Youn Soo} and Yuichi Yamasaki and Masaki Sekino and Shoogo Ueno and Eiji Kaneko and Kentaro Shimokado and Kazunori Kataoka",

year = "2006",

language = "English",

pages = "1986",

note = "55th SPSJ Annual Meeting ; Conference date: 24-05-2006 Through 26-05-2006",

}

TY - CONF

T1 - In vivo magnetic resonance detecting by using tumor-targeted polymeric micelle encapsulated iron hydroxide colloids

AU - Kumagai, Michiaki

AU - Imai, Yutaka

AU - Bae, Youn Soo

AU - Yamasaki, Yuichi

AU - Sekino, Masaki

AU - Ueno, Shoogo

AU - Kaneko, Eiji

AU - Shimokado, Kentaro

AU - Kataoka, Kazunori

PY - 2006

Y1 - 2006

N2 - We have reported the poly(ethylene glycol) - poly(amino acid) block copolymer micelles encapsulating β-FcOOH nanoparticles as tumor-targeted contrast agent for magnetic resonance imaging(MRI). PEG-PAsp molecules are multi-valently bound to the surface of the iron oxide nanoparticles via coordination between the carboxylic acid from the PAsp segment of block copolymer and Fe on the surface of iron hydroxide nanoparticles. Hence the resultant nanoparticles possess excellent solubility and stability in aqueous solution as well as in physiological saline.

AB - We have reported the poly(ethylene glycol) - poly(amino acid) block copolymer micelles encapsulating β-FcOOH nanoparticles as tumor-targeted contrast agent for magnetic resonance imaging(MRI). PEG-PAsp molecules are multi-valently bound to the surface of the iron oxide nanoparticles via coordination between the carboxylic acid from the PAsp segment of block copolymer and Fe on the surface of iron hydroxide nanoparticles. Hence the resultant nanoparticles possess excellent solubility and stability in aqueous solution as well as in physiological saline.

KW - Contrast agent

KW - MRI

KW - Polymeric micelle

KW - β-FeOOH

UR - http://www.scopus.com/inward/record.url?scp=33749873723&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749873723&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33749873723

SP - 1986

T2 - 55th SPSJ Annual Meeting

Y2 - 24 May 2006 through 26 May 2006

ER -

In vivo magnetic resonance detecting by using tumor-targeted polymeric micelle encapsulated iron hydroxide colloids

Abstract

Conference

Keywords

ASJC Scopus subject areas

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