In vivo protective effect of crocetin on benzo(a)pyrene-induced lung cancer in swiss albino mice

Venkatraman Magesh, Konga Durga Bhavani, Palaniyandi Senthilnathan, Peramaiyan Rajendran, Dhanapal Sakthisekaran

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The objective of this investigation was to determine the efficacy of crocetin in preventing lung tumorigenesis in mice. We evaluated crocetin in Swiss albino mice treated with the tobacco-specific carcinogen benzo(a)pyrene [B(a)P] for their ability to inhibit pulmonary adenoma formation and growth. Male Swiss albino mice (7 weeks old) were given 100 mg/kg B(a)P by i.p. injection, and 4 or 14 weeks later, they were given crocetin 50 mg/kg by i.p. injection 3 days/week. Crocetin (50 mg/kg body weight) reduced proliferating cells by 68% and 45% in 18 and 8 weeks of treatment respectively. The levels of glycoproteins and polyamines were significantly altered in the B(a)P-induced animals than in crocetin treatment groups. The activity of cro- cetin was more pronounced in the cancer. Taken together, these results indicate that crocetin was capable of inhibiting proliferation cells by inhibiting proliferating cells, glycoprotein and polyamine synthesis.

Original languageEnglish
Pages (from-to)533-539
Number of pages7
JournalPhytotherapy Research
Volume23
Issue number4
DOIs
StatePublished - Apr 2009

Keywords

  • B(a)P
  • Glycoprotein
  • PCNA
  • Polyamines

ASJC Scopus subject areas

  • Pharmacology

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