Incorporation and visualization of azido-functionalized: N -oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells

T. Walter, L. Collenburg, L. Japtok, B. Kleuser, S. Schneider-Schaulies, N. Müller, J. Becam, A. Schubert-Unkmeir, J. N. Kong, E. Bieberich, J. Seibel

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The synthesis and biological evaluation of azido-N-oleoyl serinol is reported. It mimicks biofunctional lipid ceramides and has shown to be capable of click reactions for cell membrane imaging in Jurkat and human brain microvascular endothelial cells.

Original languageEnglish
Pages (from-to)8612-8614
Number of pages3
JournalChemical Communications
Volume52
Issue number55
DOIs
StatePublished - 2016

Bibliographical note

Funding Information:
This study was funded through the Deutsche Forschungsgemeinschaft (RU2123) and NIH grants R01 R01AG034389 and R56NS095215 (to E. B.)

Publisher Copyright:
© 2016 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry (all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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