Incorporation and visualization of azido-functionalized: N -oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells

T. Walter; L. Collenburg; L. Japtok; B. Kleuser; S. Schneider-Schaulies; N. Müller; J. Becam; A. Schubert-Unkmeir; J. N. Kong; E. Bieberich; J. Seibel

doi:10.1039/c6cc02879a

Incorporation and visualization of azido-functionalized: N -oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells

T. Walter, L. Collenburg, L. Japtok, B. Kleuser, S. Schneider-Schaulies, N. Müller, J. Becam, A. Schubert-Unkmeir, J. N. Kong, E. Bieberich, J. Seibel

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The synthesis and biological evaluation of azido-N-oleoyl serinol is reported. It mimicks biofunctional lipid ceramides and has shown to be capable of click reactions for cell membrane imaging in Jurkat and human brain microvascular endothelial cells.

Original language	English
Pages (from-to)	8612-8614
Number of pages	3
Journal	Chemical Communications
Volume	52
Issue number	55
DOIs	https://doi.org/10.1039/c6cc02879a
State	Published - 2016

Bibliographical note

Publisher Copyright:
© 2016 The Royal Society of Chemistry.

Funding

This study was funded through the Deutsche Forschungsgemeinschaft (RU2123) and NIH grants R01 R01AG034389 and R56NS095215 (to E. B.)

Funders	Funder number
National Institutes of Health (NIH)	R01 R01AG034389
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council	R56NS095215
Deutsche Forschungsgemeinschaft	RU2123

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c6cc02879a

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Walter, T., Collenburg, L., Japtok, L., Kleuser, B., Schneider-Schaulies, S., Müller, N., Becam, J., Schubert-Unkmeir, A., Kong, J. N., Bieberich, E., & Seibel, J. (2016). Incorporation and visualization of azido-functionalized: N -oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells. Chemical Communications, 52(55), 8612-8614. https://doi.org/10.1039/c6cc02879a

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title = "Incorporation and visualization of azido-functionalized: N -oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells",

abstract = "The synthesis and biological evaluation of azido-N-oleoyl serinol is reported. It mimicks biofunctional lipid ceramides and has shown to be capable of click reactions for cell membrane imaging in Jurkat and human brain microvascular endothelial cells.",

author = "T. Walter and L. Collenburg and L. Japtok and B. Kleuser and S. Schneider-Schaulies and N. M{\"u}ller and J. Becam and A. Schubert-Unkmeir and Kong, \{J. N.\} and E. Bieberich and J. Seibel",

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doi = "10.1039/c6cc02879a",

language = "English",

volume = "52",

pages = "8612--8614",

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Walter, T, Collenburg, L, Japtok, L, Kleuser, B, Schneider-Schaulies, S, Müller, N, Becam, J, Schubert-Unkmeir, A, Kong, JN, Bieberich, E & Seibel, J 2016, 'Incorporation and visualization of azido-functionalized: N -oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells', Chemical Communications, vol. 52, no. 55, pp. 8612-8614. https://doi.org/10.1039/c6cc02879a

TY - JOUR

T1 - Incorporation and visualization of azido-functionalized

T2 - N -oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells

AU - Walter, T.

AU - Collenburg, L.

AU - Japtok, L.

AU - Kleuser, B.

AU - Schneider-Schaulies, S.

AU - Müller, N.

AU - Becam, J.

AU - Schubert-Unkmeir, A.

AU - Kong, J. N.

AU - Bieberich, E.

AU - Seibel, J.

PY - 2016

Y1 - 2016

N2 - The synthesis and biological evaluation of azido-N-oleoyl serinol is reported. It mimicks biofunctional lipid ceramides and has shown to be capable of click reactions for cell membrane imaging in Jurkat and human brain microvascular endothelial cells.

AB - The synthesis and biological evaluation of azido-N-oleoyl serinol is reported. It mimicks biofunctional lipid ceramides and has shown to be capable of click reactions for cell membrane imaging in Jurkat and human brain microvascular endothelial cells.

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JO - Chemical Communications

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Incorporation and visualization of azido-functionalized: N -oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

Access to Document

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