Increase in sensorimotor cortex response to somatosensory stimulation over subacute poststroke period correlates with motor recovery in hemiparetic patients

Judith D. Schaechter; Casper A.M.M. Van Oers; Benjamin N. Groisser; Sara S. Salles; Mark G. Vangel; Christopher I. Moore; Rick M. Dijkhuizen

doi:10.1177/1545968311421613

Increase in sensorimotor cortex response to somatosensory stimulation over subacute poststroke period correlates with motor recovery in hemiparetic patients

Judith D. Schaechter, Casper A.M.M. Van Oers, Benjamin N. Groisser, Sara S. Salles, Mark G. Vangel, Christopher I. Moore, Rick M. Dijkhuizen

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Background. Somatosensory input to the motor cortex may play a critical role in motor relearning after hemiparetic stroke. Objective. The authors tested the hypothesis that motor recovery after hemiparetic stroke relates to changes in responsiveness of the sensorimotor cortex (SMC) to somatosensory input. Methods. A total of 10 hemiparetic stroke patients underwent serial functional magnetic resonance imaging (fMRI) during tactile stimulation and testing of sensorimotor function over 1 year-at early subacute, late subacute, and chronic poststroke time points. Results. Over the subacute poststroke period, increased responsiveness of the ipsilesional SMC to tactile stimulation of a stroke-affected digit correlated strongly with concurrent gains in motor function. Increased responsiveness of the ipsilesional and contralesional SMC over the subacute period also correlated strongly with motor recovery experienced over the first year poststroke. Conclusions. These findings suggest that increased responsiveness of the SMC to somatosensory stimulation over the subacute poststroke period may contribute to motor recovery.

Original language	English
Pages (from-to)	325-334
Number of pages	10
Journal	Neurorehabilitation and Neural Repair
Volume	26
Issue number	4
DOIs	https://doi.org/10.1177/1545968311421613
State	Published - May 2012

Funding

This study was supported by grants from the American Heart Association–New England Affiliate (to JDS and RMD), the Royal Netherlands Academy of Arts and Sciences (to RMD), the Netherlands Heart Foundation (2003B196), the National Institutes of Health K23-HD044425 (to JDS), NCRR (P41-RR14075), and the MIND Institute.

Funders	Funder number
Netherlands Heart Foundation	2003B196
National Institutes of Health (NIH)	K23-HD044425
National Center for Research Resources	P41RR014075
American the American Heart Association
Mind and Life Institute
Koninklijke Nederlandse Akademie van Wetenschappen

Keywords

functional MRI
motor function
plasticity
somatosensory
tactile

ASJC Scopus subject areas

Rehabilitation
Neurology
Clinical Neurology

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10.1177/1545968311421613

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Schaechter, J. D., Van Oers, C. A. M. M., Groisser, B. N., Salles, S. S., Vangel, M. G., Moore, C. I., & Dijkhuizen, R. M. (2012). Increase in sensorimotor cortex response to somatosensory stimulation over subacute poststroke period correlates with motor recovery in hemiparetic patients. Neurorehabilitation and Neural Repair, 26(4), 325-334. https://doi.org/10.1177/1545968311421613

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title = "Increase in sensorimotor cortex response to somatosensory stimulation over subacute poststroke period correlates with motor recovery in hemiparetic patients",

abstract = "Background. Somatosensory input to the motor cortex may play a critical role in motor relearning after hemiparetic stroke. Objective. The authors tested the hypothesis that motor recovery after hemiparetic stroke relates to changes in responsiveness of the sensorimotor cortex (SMC) to somatosensory input. Methods. A total of 10 hemiparetic stroke patients underwent serial functional magnetic resonance imaging (fMRI) during tactile stimulation and testing of sensorimotor function over 1 year-at early subacute, late subacute, and chronic poststroke time points. Results. Over the subacute poststroke period, increased responsiveness of the ipsilesional SMC to tactile stimulation of a stroke-affected digit correlated strongly with concurrent gains in motor function. Increased responsiveness of the ipsilesional and contralesional SMC over the subacute period also correlated strongly with motor recovery experienced over the first year poststroke. Conclusions. These findings suggest that increased responsiveness of the SMC to somatosensory stimulation over the subacute poststroke period may contribute to motor recovery.",

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author = "Schaechter, \{Judith D.\} and \{Van Oers\}, \{Casper A.M.M.\} and Groisser, \{Benjamin N.\} and Salles, \{Sara S.\} and Vangel, \{Mark G.\} and Moore, \{Christopher I.\} and Dijkhuizen, \{Rick M.\}",

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Schaechter, JD, Van Oers, CAMM, Groisser, BN, Salles, SS, Vangel, MG, Moore, CI & Dijkhuizen, RM 2012, 'Increase in sensorimotor cortex response to somatosensory stimulation over subacute poststroke period correlates with motor recovery in hemiparetic patients', Neurorehabilitation and Neural Repair, vol. 26, no. 4, pp. 325-334. https://doi.org/10.1177/1545968311421613

Increase in sensorimotor cortex response to somatosensory stimulation over subacute poststroke period correlates with motor recovery in hemiparetic patients. / Schaechter, Judith D.; Van Oers, Casper A.M.M.; Groisser, Benjamin N. et al.
In: Neurorehabilitation and Neural Repair, Vol. 26, No. 4, 05.2012, p. 325-334.

Research output: Contribution to journal › Article › peer-review

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AU - Van Oers, Casper A.M.M.

AU - Groisser, Benjamin N.

AU - Salles, Sara S.

AU - Vangel, Mark G.

AU - Moore, Christopher I.

AU - Dijkhuizen, Rick M.

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AB - Background. Somatosensory input to the motor cortex may play a critical role in motor relearning after hemiparetic stroke. Objective. The authors tested the hypothesis that motor recovery after hemiparetic stroke relates to changes in responsiveness of the sensorimotor cortex (SMC) to somatosensory input. Methods. A total of 10 hemiparetic stroke patients underwent serial functional magnetic resonance imaging (fMRI) during tactile stimulation and testing of sensorimotor function over 1 year-at early subacute, late subacute, and chronic poststroke time points. Results. Over the subacute poststroke period, increased responsiveness of the ipsilesional SMC to tactile stimulation of a stroke-affected digit correlated strongly with concurrent gains in motor function. Increased responsiveness of the ipsilesional and contralesional SMC over the subacute period also correlated strongly with motor recovery experienced over the first year poststroke. Conclusions. These findings suggest that increased responsiveness of the SMC to somatosensory stimulation over the subacute poststroke period may contribute to motor recovery.

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Increase in sensorimotor cortex response to somatosensory stimulation over subacute poststroke period correlates with motor recovery in hemiparetic patients

Abstract

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ASJC Scopus subject areas

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