'Increased calcium-current' hypothesis of brain aging

Philip W. Landfield

doi:10.1016/0197-4580(87)90074-1

'Increased calcium-current' hypothesis of brain aging

Philip W. Landfield

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

176 Scopus citations

Abstract

Based on evidence that high Mg²⁺ counteracts age-related declines in synaptic plasticity, and that aged rat hippocampal neurons exhibit prolonged Ca²⁺-dependent K⁺ currents, it is proposed that an underlying cause of altered Ca²⁺ homeostasis during brain aging may be an increased membrane conductance to Ca²⁺. An apparent Ca²⁺-mediated inactivation of Ca²⁺ current, which was recently described in hippocampus, could account for some of the contradictions in the literature.

Original language	English
Pages (from-to)	346-347
Number of pages	2
Journal	Neurobiology of Aging
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/0197-4580(87)90074-1
State	Published - 1987

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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abstract = "Based on evidence that high Mg2+ counteracts age-related declines in synaptic plasticity, and that aged rat hippocampal neurons exhibit prolonged Ca2+-dependent K+ currents, it is proposed that an underlying cause of altered Ca2+ homeostasis during brain aging may be an increased membrane conductance to Ca2+. An apparent Ca2+-mediated inactivation of Ca2+ current, which was recently described in hippocampus, could account for some of the contradictions in the literature.",

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AB - Based on evidence that high Mg2+ counteracts age-related declines in synaptic plasticity, and that aged rat hippocampal neurons exhibit prolonged Ca2+-dependent K+ currents, it is proposed that an underlying cause of altered Ca2+ homeostasis during brain aging may be an increased membrane conductance to Ca2+. An apparent Ca2+-mediated inactivation of Ca2+ current, which was recently described in hippocampus, could account for some of the contradictions in the literature.

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'Increased calcium-current' hypothesis of brain aging

Abstract

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