'Increased calcium-current' hypothesis of brain aging

Philip W. Landfield

Research output: Contribution to journalArticlepeer-review

172 Scopus citations


Based on evidence that high Mg2+ counteracts age-related declines in synaptic plasticity, and that aged rat hippocampal neurons exhibit prolonged Ca2+-dependent K+ currents, it is proposed that an underlying cause of altered Ca2+ homeostasis during brain aging may be an increased membrane conductance to Ca2+. An apparent Ca2+-mediated inactivation of Ca2+ current, which was recently described in hippocampus, could account for some of the contradictions in the literature.

Original languageEnglish
Pages (from-to)346-347
Number of pages2
JournalNeurobiology of Aging
Issue number4
StatePublished - 1987

ASJC Scopus subject areas

  • Neuroscience (all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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