Increased chloride transport in erythrocytes in Huntington's disease

W. A. Bialas; W. R. Markesbery; D. A. Butterfield

doi:10.1016/S0006-291X(80)80121-5

Increased chloride transport in erythrocytes in Huntington's disease

W. A. Bialas, W. R. Markesbery, D. A. Butterfield

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Studies of ³⁶Cl⁻ efflux across erythrocyte membranes in controls and Huntington's disease have been performed. An increased rate constant for ³⁶Cl⁻ efflux in fresh Huntington's disease erythrocytes compared to normal controls was observed (P<0.01) in blind studies. Chloride transport is regulated in human erythrocytes at the external aspect of Band 3, the major red cell transmembrane protein. The present results on tissue completely outside the central nervous system are consistent with our suggestion that Huntington's disease is associated with a generalized membrane defect located at the external cell surface [Butterfield et al (1980) Life Sciences 27, 609–615].

Original language	English
Pages (from-to)	1895-1900
Number of pages	6
Journal	Topics in Catalysis
Volume	95
Issue number	4
DOIs	https://doi.org/10.1016/S0006-291X(80)80121-5
State	Published - 1980

Bibliographical note

Funding Information:
This work was supported in part by the National Institutes of Health (NS-13791-03 and N8-14221) and the Muscular Dystrophy Association of America.

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Biophysics
Molecular Biology

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10.1016/S0006-291X(80)80121-5

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title = "Increased chloride transport in erythrocytes in Huntington's disease",

abstract = "Studies of 36Cl− efflux across erythrocyte membranes in controls and Huntington's disease have been performed. An increased rate constant for 36Cl− efflux in fresh Huntington's disease erythrocytes compared to normal controls was observed (P<0.01) in blind studies. Chloride transport is regulated in human erythrocytes at the external aspect of Band 3, the major red cell transmembrane protein. The present results on tissue completely outside the central nervous system are consistent with our suggestion that Huntington's disease is associated with a generalized membrane defect located at the external cell surface [Butterfield et al (1980) Life Sciences 27, 609–615].",

author = "Bialas, {W. A.} and Markesbery, {W. R.} and Butterfield, {D. A.}",

note = "Funding Information: This work was supported in part by the National Institutes of Health (NS-13791-03 and N8-14221) and the Muscular Dystrophy Association of America.",

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AU - Bialas, W. A.

AU - Markesbery, W. R.

AU - Butterfield, D. A.

N1 - Funding Information: This work was supported in part by the National Institutes of Health (NS-13791-03 and N8-14221) and the Muscular Dystrophy Association of America.

PY - 1980

Y1 - 1980

N2 - Studies of 36Cl− efflux across erythrocyte membranes in controls and Huntington's disease have been performed. An increased rate constant for 36Cl− efflux in fresh Huntington's disease erythrocytes compared to normal controls was observed (P<0.01) in blind studies. Chloride transport is regulated in human erythrocytes at the external aspect of Band 3, the major red cell transmembrane protein. The present results on tissue completely outside the central nervous system are consistent with our suggestion that Huntington's disease is associated with a generalized membrane defect located at the external cell surface [Butterfield et al (1980) Life Sciences 27, 609–615].

AB - Studies of 36Cl− efflux across erythrocyte membranes in controls and Huntington's disease have been performed. An increased rate constant for 36Cl− efflux in fresh Huntington's disease erythrocytes compared to normal controls was observed (P<0.01) in blind studies. Chloride transport is regulated in human erythrocytes at the external aspect of Band 3, the major red cell transmembrane protein. The present results on tissue completely outside the central nervous system are consistent with our suggestion that Huntington's disease is associated with a generalized membrane defect located at the external cell surface [Butterfield et al (1980) Life Sciences 27, 609–615].

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Increased chloride transport in erythrocytes in Huntington's disease

Abstract

Bibliographical note

ASJC Scopus subject areas

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