Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease

James W. Geddes; John Wong; Ben H. Choi; Ronald C. Kim; Carl W. Cotman; Freda D. Miller

doi:10.1016/0304-3940(90)90537-J

Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease

James W. Geddes, John Wong, Ben H. Choi, Ronald C. Kim, Carl W. Cotman, Freda D. Miller

Neuroscience

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

There is increasing evidence that an aberrant sprouting response may contribute to some of the neuronal alterations observed in Alzheimer's disease (AD). In this study, we demonstrate that in the rat CNS, sprouting results in the reinduction of the embryonic form of the mRNA for α-tubulin. The fetal form of α-tubulin mRNA was also elevated in the hippocampus obtained from five AD patients, as compared to five elderly controls. These results suggest that the reexpression of embryonic forms of cytoskeletal proteins, in association with an aberrant sprouting response, may contribute to the neuropathological alterations in AD.

Original language	English
Pages (from-to)	54-61
Number of pages	8
Journal	Neuroscience Letters
Volume	109
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(90)90537-J
State	Published - Feb 5 1990

Bibliographical note

Funding Information:
We thank Suzanne Cooper and Lenna Mah for excellent technical assistance and Ann Clark, Jennifer Kahle, Rich Murphy, and Ann Atchison for critical reviews of the manuscript. This work was supported by a NIA LEAD award and by a Medical Research Council (Canada) grant. F.D.M. is an Alberta Heritage Foundation Medical Research Scholar and this study was completed during the tenure of J.W.G. as a National Down Syndrome Society Science Scholar.

Keywords

Alzheimer's disease
Development
In situ hybridization
Messenger RNA
Sprouting
Tubulin

ASJC Scopus subject areas

Neuroscience (all)

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10.1016/0304-3940(90)90537-J

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title = "Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease",

abstract = "There is increasing evidence that an aberrant sprouting response may contribute to some of the neuronal alterations observed in Alzheimer's disease (AD). In this study, we demonstrate that in the rat CNS, sprouting results in the reinduction of the embryonic form of the mRNA for α-tubulin. The fetal form of α-tubulin mRNA was also elevated in the hippocampus obtained from five AD patients, as compared to five elderly controls. These results suggest that the reexpression of embryonic forms of cytoskeletal proteins, in association with an aberrant sprouting response, may contribute to the neuropathological alterations in AD.",

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AU - Cotman, Carl W.

AU - Miller, Freda D.

N1 - Funding Information: We thank Suzanne Cooper and Lenna Mah for excellent technical assistance and Ann Clark, Jennifer Kahle, Rich Murphy, and Ann Atchison for critical reviews of the manuscript. This work was supported by a NIA LEAD award and by a Medical Research Council (Canada) grant. F.D.M. is an Alberta Heritage Foundation Medical Research Scholar and this study was completed during the tenure of J.W.G. as a National Down Syndrome Society Science Scholar.

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N2 - There is increasing evidence that an aberrant sprouting response may contribute to some of the neuronal alterations observed in Alzheimer's disease (AD). In this study, we demonstrate that in the rat CNS, sprouting results in the reinduction of the embryonic form of the mRNA for α-tubulin. The fetal form of α-tubulin mRNA was also elevated in the hippocampus obtained from five AD patients, as compared to five elderly controls. These results suggest that the reexpression of embryonic forms of cytoskeletal proteins, in association with an aberrant sprouting response, may contribute to the neuropathological alterations in AD.

AB - There is increasing evidence that an aberrant sprouting response may contribute to some of the neuronal alterations observed in Alzheimer's disease (AD). In this study, we demonstrate that in the rat CNS, sprouting results in the reinduction of the embryonic form of the mRNA for α-tubulin. The fetal form of α-tubulin mRNA was also elevated in the hippocampus obtained from five AD patients, as compared to five elderly controls. These results suggest that the reexpression of embryonic forms of cytoskeletal proteins, in association with an aberrant sprouting response, may contribute to the neuropathological alterations in AD.

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KW - Development

KW - In situ hybridization

KW - Messenger RNA

KW - Sprouting

KW - Tubulin

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Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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