Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice

Medicine and Dentistry

• Dopamine 83%
• Gene 66%
• Calcium Ion 66%
• Dopamine Agonist 66%
• Innate Immunity 50%
• Cytokine 50%
• Phosphotransferase 50%
• Programmed Cell Death 33%
• Lipopolysaccharide 33%
• Amino Terminal Sequence 33%
• Brain Mitochondrion 33%
• Serositis 16%
• Signal Transduction 16%
• Parkinson's Disease 16%
• Injury 16%
• Metabolism 16%
• Homeostasis 16%
• Mitochondrial Respiration 16%
• Regeneration 16%
• Isotopes of Calcium 16%
• Neurodegeneration 16%
• Fibroblast 16%
• Lesion 16%
• Immunoglobulin Enhancer Binding Protein 16%
• Cyclosporine 16%
• Dopamine Release 16%
• Parkinsonism 16%
• Nuclear Factor 16%
• Gene Expression Profiling 16%
• Mitochondrial Permeability 16%
• Sprouting 16%
• Differential Gene Expression 16%

Neuroscience

• Striatum 100%
• Dopamine 83%
• Gene 66%
• Neuron 66%
• Brain 66%
• Dopaminergic 66%
• Kinase 50%
• Mitochondrion 33%
• Substantia nigra 33%
• Lipopolysaccharide 33%
• Amino Terminal Sequence 33%
• Familial Parkinson's Disease 33%
• Neurodegeneration 16%
• Parkinson's Disease 16%
• Gene Expression 16%
• Cell Signaling 16%
• Mitochondrial Respiration 16%
• Parkinsonism 16%
• Immunoglobulin Enhancer Binding Protein 16%
• Apoptosis 16%
• Dopamine Release 16%
• Fibroblast 16%
• Nuclear Factor 16%
• Ciclosporin 16%
• Mitochondrial Permeability 16%