TY - JOUR
T1 - Increased protein and lipid oxidative damage in mitochondria isolated from lymphocytes from patients with alzheimer's disease
T2 - Insights into the role of oxidative stress in alzheimer's disease and initial investigations into a potential biomarker for this dementing disorder
AU - Sultana, Rukhsana
AU - Mecocci, Patrizia
AU - Mangialasche, Francesca
AU - Cecchetti, Roberta
AU - Baglioni, Mauro
AU - Butterfield, D. Allan
PY - 2011
Y1 - 2011
N2 - Alzheimer's disease (AD) is histopathologically characterized by the presence of senile plaques, neurofibrillary tangles, and synapse loss. The main component of senile plaques is amyloid β-peptide (Aβ), which has been shown to induce oxidative stress in in vitro and in vivo studies. AD is associated with elevated levels of oxidative damage in brain and peripheral lymphocytes. Further Aβ has been found to be accumulated in mitochondria, which might contribute to the reported alterations in the mitochondrial morphology, and impaired mitochondrial energy metabolism in AD brain. Biomarkers are desperately needed for earlier diagnosis of AD and to monitor efficacy of new therapies. Hence, in the present study we show that markers of oxidative damage are elevated in mitochondria isolated from AD lymphocytes suggesting that these oxidative stress indices potentially could serve as a viable biomarker for AD.
AB - Alzheimer's disease (AD) is histopathologically characterized by the presence of senile plaques, neurofibrillary tangles, and synapse loss. The main component of senile plaques is amyloid β-peptide (Aβ), which has been shown to induce oxidative stress in in vitro and in vivo studies. AD is associated with elevated levels of oxidative damage in brain and peripheral lymphocytes. Further Aβ has been found to be accumulated in mitochondria, which might contribute to the reported alterations in the mitochondrial morphology, and impaired mitochondrial energy metabolism in AD brain. Biomarkers are desperately needed for earlier diagnosis of AD and to monitor efficacy of new therapies. Hence, in the present study we show that markers of oxidative damage are elevated in mitochondria isolated from AD lymphocytes suggesting that these oxidative stress indices potentially could serve as a viable biomarker for AD.
KW - 3-nitrotyrosine
KW - Alzheimer's disease
KW - lymphocytes
KW - mitochondria
KW - oxidative stress
KW - protein carbonyls
KW - protein-bound 4 hydroxy-2 trans nonenal
UR - http://www.scopus.com/inward/record.url?scp=79955658979&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955658979&partnerID=8YFLogxK
U2 - 10.3233/JAD-2011-101425
DO - 10.3233/JAD-2011-101425
M3 - Article
C2 - 21383494
AN - SCOPUS:79955658979
SN - 1387-2877
VL - 24
SP - 77
EP - 84
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 1
ER -