Increased risk for meningococcal disease among men who have sex with men in the United States, 2012-2015

Temitope A. Folaranmi, Cecilia B. Kretz, Hajime Kamiya, Jessica R. MacNeil, Melissa J. Whaley, Amy Blain, Mike Antwi, Marie Dorsinville, Massimo Pacilli, Shamika Smith, Rachel Civen, Van Ngo, Kathleen Winter, Kathleen Harriman, Xin Wang, Virginia B. Bowen, Manisha Patel, Stacey Martin, Lara Misegades, Sarah A. Meyer

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Background. Several clusters of serogroup C meningococcal disease among men who have sex with men (MSM) have been reported in the United States in recent years. The epidemiology and risk of meningococcal disease among MSM is not well described. Methods. All meningococcal disease cases among men aged 18-64 years reported to the National Notifiable Disease Surveillance System between January 2012 and June 2015 were reviewed. Characteristics of meningococcal disease cases among MSM and men not known to be MSM (non-MSM) were described. Annualized incidence rates among MSM and non-MSM were compared through calculation of the relative risk and 95% confidence intervals. Isolates from meningococcal disease cases among MSM were characterized using standard microbiological methods and whole-genome sequencing. Results. Seventy-four cases of meningococcal disease were reported among MSM and 453 among non-MSM. Annualized incidence of meningococcal disease among MSM was 0.56 cases per 100 000 population, compared to 0.14 among non-MSM, for a relative risk of 4.0 (95% confidence interval [CI], 3.1-5.1). Among the 64 MSM with known status, 38 (59%) were infected with human immunodeficiency virus (HIV). HIV-infected MSM had 10.1 times (95% CI, 6.1-16.6) the risk of HIV-uninfected MSM. All isolates from cluster-associated cases were serogroup C sequence type 11. Conclusions. MSM are at increased risk for meningococcal disease, although the incidence of disease remains low. HIV infection may be an important factor for this increased risk. Routine vaccination of HIV-infected persons with a quadrivalent meningococcal conjugate vaccine in accordance with Advisory Committee on Immunization Practices recommendations should be encouraged.

Original languageEnglish
Pages (from-to)756-763
Number of pages8
JournalClinical Infectious Diseases
Volume65
Issue number5
DOIs
StatePublished - Sep 1 2017

Bibliographical note

Funding Information:
Disclaimer. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention (CDC). Financial support. This work was supported by the CDC.

Publisher Copyright:
© Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

Keywords

  • Homosexuality
  • Male
  • Meningococcal infections
  • Neisseria meningitidis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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