Increased sodium plus potassium adenosine triphosphatase activity in erythrocyte membranes in Huntington's disease

D. A. Butterfield; J. Q. Oeswein; M. E. Prunty; K. C. Hisle; W. R. Markesbery

doi:10.1002/ana.410040111

Increased sodium plus potassium adenosine triphosphatase activity in erythrocyte membranes in Huntington's disease

D. A. Butterfield, J. Q. Oeswein, M. E. Prunty, K. C. Hisle, W. R. Markesbery

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Abstract

Dopa‐decarboxylase, acetylcholinesterase, sodium plus potassium stimulated adenosine triphosphatase (Na⁺ + K⁺ − ATPase), and membrane‐bound protein kinase were compared in the erythrocytes of patients with Huntington's disease and normal controls. All these enzymes also exist in the basal ganglia. The Na⁺ + K⁺‐ATPase level was elevated (p < 0.05) in Huntington's disease, while no significant changes were observed in the other enzymes. This finding is consistent with the concept that Huntington's disease is associated with a general membrane abnormality.

Original language	English
Pages (from-to)	60-62
Number of pages	3
Journal	Annals of Neurology
Volume	4
Issue number	1
DOIs	https://doi.org/10.1002/ana.410040111
State	Published - Jul 1978

ASJC Scopus subject areas

Neurology
Clinical Neurology

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abstract = "Dopa‐decarboxylase, acetylcholinesterase, sodium plus potassium stimulated adenosine triphosphatase (Na+ + K+ − ATPase), and membrane‐bound protein kinase were compared in the erythrocytes of patients with Huntington's disease and normal controls. All these enzymes also exist in the basal ganglia. The Na+ + K+‐ATPase level was elevated (p < 0.05) in Huntington's disease, while no significant changes were observed in the other enzymes. This finding is consistent with the concept that Huntington's disease is associated with a general membrane abnormality.",

author = "Butterfield, {D. A.} and Oeswein, {J. Q.} and Prunty, {M. E.} and Hisle, {K. C.} and Markesbery, {W. R.}",

year = "1978",

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AU - Butterfield, D. A.

AU - Oeswein, J. Q.

AU - Prunty, M. E.

AU - Hisle, K. C.

AU - Markesbery, W. R.

PY - 1978/7

Y1 - 1978/7

N2 - Dopa‐decarboxylase, acetylcholinesterase, sodium plus potassium stimulated adenosine triphosphatase (Na+ + K+ − ATPase), and membrane‐bound protein kinase were compared in the erythrocytes of patients with Huntington's disease and normal controls. All these enzymes also exist in the basal ganglia. The Na+ + K+‐ATPase level was elevated (p < 0.05) in Huntington's disease, while no significant changes were observed in the other enzymes. This finding is consistent with the concept that Huntington's disease is associated with a general membrane abnormality.

AB - Dopa‐decarboxylase, acetylcholinesterase, sodium plus potassium stimulated adenosine triphosphatase (Na+ + K+ − ATPase), and membrane‐bound protein kinase were compared in the erythrocytes of patients with Huntington's disease and normal controls. All these enzymes also exist in the basal ganglia. The Na+ + K+‐ATPase level was elevated (p < 0.05) in Huntington's disease, while no significant changes were observed in the other enzymes. This finding is consistent with the concept that Huntington's disease is associated with a general membrane abnormality.

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Increased sodium plus potassium adenosine triphosphatase activity in erythrocyte membranes in Huntington's disease

Abstract

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