Increased sodium plus potassium adenosine triphosphatase activity in erythrocyte membranes in Huntington's disease

D. A. Butterfield, J. Q. Oeswein, M. E. Prunty, K. C. Hisle, W. R. Markesbery

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Dopa‐decarboxylase, acetylcholinesterase, sodium plus potassium stimulated adenosine triphosphatase (Na+ + K+ − ATPase), and membrane‐bound protein kinase were compared in the erythrocytes of patients with Huntington's disease and normal controls. All these enzymes also exist in the basal ganglia. The Na+ + K+‐ATPase level was elevated (p < 0.05) in Huntington's disease, while no significant changes were observed in the other enzymes. This finding is consistent with the concept that Huntington's disease is associated with a general membrane abnormality.

Original languageEnglish
Pages (from-to)60-62
Number of pages3
JournalAnnals of Neurology
Volume4
Issue number1
DOIs
StatePublished - Jul 1978

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Increased sodium plus potassium adenosine triphosphatase activity in erythrocyte membranes in Huntington's disease'. Together they form a unique fingerprint.

Cite this