TY - JOUR
T1 - Increases in SLT2 expression and chitin content are associated with incomplete killing of Candida glabrata by caspofungin
AU - Cota, Jason M.
AU - Grabinski, Jodi L.
AU - Talbert, Robert L.
AU - Burgess, David S.
AU - Rogers, P. David
AU - Edlind, Thomas D.
AU - Wiederhold, Nathan P.
PY - 2008/3
Y1 - 2008/3
N2 - Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Δslt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.
AB - Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Δslt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.
UR - http://www.scopus.com/inward/record.url?scp=40549084007&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40549084007&partnerID=8YFLogxK
U2 - 10.1128/AAC.01542-07
DO - 10.1128/AAC.01542-07
M3 - Article
C2 - 18086838
AN - SCOPUS:40549084007
SN - 0066-4804
VL - 52
SP - 1144
EP - 1146
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 3
ER -