Increasing adipocyte lipoprotein lipase improves glucose metabolism in high fat diet-induced obesity

R. Grace Walton; Beibei Zhu; Resat Unal; Michael Spencer; Manjula Sunkara; Andrew J. Morris; Richard Charnigo; Wendy S. Katz; Alan Daugherty; Deborah A. Howatt‡; Philip A. Kern; Brian S. Finlin

doi:10.1074/jbc.M114.628487

Increasing adipocyte lipoprotein lipase improves glucose metabolism in high fat diet-induced obesity

R. Grace Walton, Beibei Zhu, Resat Unal, Michael Spencer, Manjula Sunkara, Andrew J. Morris, Richard Charnigo, Wendy S. Katz, Alan Daugherty, Deborah A. Howatt‡, Philip A. Kern, Brian S. Finlin

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Background: Lipoprotein lipase regulates fat uptake into adipose tissue. Results: A mouse model with increased adipose tissue lipoprotein lipase has improved glucose metabolism when challenged with a high fat diet. Conclusion: Increasing adipose tissue lipoprotein lipase improves adipose tissue function. Significance: Adipose tissue lipoprotein lipase protects against obesity-induced glucose and insulin intolerance.

Original language	English
Pages (from-to)	11547-11556
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	290
Issue number	18
DOIs	https://doi.org/10.1074/jbc.M114.628487
State	Published - May 1 2015

Bibliographical note

Publisher Copyright:
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Funding

Funders	Funder number
National Institute of General Medical Sciences	DK039176, DK071349
National Center for Advancing Translational Sciences (NCATS)	UL1TR000117
National Center for Advancing Translational Sciences (NCATS)

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1074/jbc.M114.628487

Cite this

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title = "Increasing adipocyte lipoprotein lipase improves glucose metabolism in high fat diet-induced obesity",

abstract = "Background: Lipoprotein lipase regulates fat uptake into adipose tissue. Results: A mouse model with increased adipose tissue lipoprotein lipase has improved glucose metabolism when challenged with a high fat diet. Conclusion: Increasing adipose tissue lipoprotein lipase improves adipose tissue function. Significance: Adipose tissue lipoprotein lipase protects against obesity-induced glucose and insulin intolerance.",

author = "Walton, \{R. Grace\} and Beibei Zhu and Resat Unal and Michael Spencer and Manjula Sunkara and Morris, \{Andrew J.\} and Richard Charnigo and Katz, \{Wendy S.\} and Alan Daugherty and Howatt‡, \{Deborah A.\} and Kern, \{Philip A.\} and Finlin, \{Brian S.\}",

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doi = "10.1074/jbc.M114.628487",

language = "English",

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AU - Walton, R. Grace

AU - Zhu, Beibei

AU - Unal, Resat

AU - Spencer, Michael

AU - Sunkara, Manjula

AU - Morris, Andrew J.

AU - Charnigo, Richard

AU - Katz, Wendy S.

AU - Daugherty, Alan

AU - Howatt‡, Deborah A.

AU - Kern, Philip A.

AU - Finlin, Brian S.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Background: Lipoprotein lipase regulates fat uptake into adipose tissue. Results: A mouse model with increased adipose tissue lipoprotein lipase has improved glucose metabolism when challenged with a high fat diet. Conclusion: Increasing adipose tissue lipoprotein lipase improves adipose tissue function. Significance: Adipose tissue lipoprotein lipase protects against obesity-induced glucose and insulin intolerance.

AB - Background: Lipoprotein lipase regulates fat uptake into adipose tissue. Results: A mouse model with increased adipose tissue lipoprotein lipase has improved glucose metabolism when challenged with a high fat diet. Conclusion: Increasing adipose tissue lipoprotein lipase improves adipose tissue function. Significance: Adipose tissue lipoprotein lipase protects against obesity-induced glucose and insulin intolerance.

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Increasing adipocyte lipoprotein lipase improves glucose metabolism in high fat diet-induced obesity

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

UN SDGs

Access to Document

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