TY - JOUR
T1 - Increasing Area Deprivation Index negatively impacts ovarian cancer survival
AU - Hufnagel, Demetra H.
AU - Khabele, Dineo
AU - Yull, Fiona E.
AU - Hull, Pamela C.
AU - Schildkraut, Joellen
AU - Crispens, Marta A.
AU - Beeghly-Fadiel, Alicia
N1 - Publisher Copyright:
© 2021
PY - 2021/10
Y1 - 2021/10
N2 - Introduction: While individual-level measures of socioeconomic status have been well-studied in relation to ovarian cancer survival, no studies to date have examined both state and national-level Area Deprivation Indices (ADIs), which incorporate neighborhood affluence and resources. Methods: We abstracted clinical data from medical records for ovarian cancer cases from the Vanderbilt University Medical Center and obtained ADIs from the Neighborhood Atlas®. Associations with clinical characteristics were assessed with Spearman correlations and Kruskal-Wallis tests; associations with progression-free survival (PFS) and overall survival (OS) were assessed with Cox proportional-hazards regression. Results: Among 184 cases, state and national ADIs were highly correlated, but not related to any cancer characteristics. In multivariable adjusted regression models, both were significantly associated with OS; each decile increase in state or national ADI corresponded to a 9 % or 10 % greater risk of death, respectively. Conclusions: Increasing area-level deprivation may negatively impact ovarian cancer survival.
AB - Introduction: While individual-level measures of socioeconomic status have been well-studied in relation to ovarian cancer survival, no studies to date have examined both state and national-level Area Deprivation Indices (ADIs), which incorporate neighborhood affluence and resources. Methods: We abstracted clinical data from medical records for ovarian cancer cases from the Vanderbilt University Medical Center and obtained ADIs from the Neighborhood Atlas®. Associations with clinical characteristics were assessed with Spearman correlations and Kruskal-Wallis tests; associations with progression-free survival (PFS) and overall survival (OS) were assessed with Cox proportional-hazards regression. Results: Among 184 cases, state and national ADIs were highly correlated, but not related to any cancer characteristics. In multivariable adjusted regression models, both were significantly associated with OS; each decile increase in state or national ADI corresponded to a 9 % or 10 % greater risk of death, respectively. Conclusions: Increasing area-level deprivation may negatively impact ovarian cancer survival.
KW - Ovarian neoplasms
KW - Prognosis
KW - Socioeconomic factors
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=85113316903&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85113316903&partnerID=8YFLogxK
U2 - 10.1016/j.canep.2021.102013
DO - 10.1016/j.canep.2021.102013
M3 - Article
C2 - 34438316
AN - SCOPUS:85113316903
SN - 1877-7821
VL - 74
JO - Cancer Epidemiology
JF - Cancer Epidemiology
M1 - 102013
ER -