Alkyl chloroformates induced indirect trapping of the retroconjugate addition reaction intermediate involved in the epimerization of lobeline is described. This strategy was applied to the conversion of (-)-lobeline to (-)-sedamine in high overall yield.
|Number of pages||4|
|Journal||Journal of Organic Chemistry|
|State||Published - Nov 26 2004|
ASJC Scopus subject areas
- Organic Chemistry