Individual differences in acute alcohol impairment of inhibitory control predict ad libitum alcohol consumption

Jessica Weafer, Mark T. Fillmore

Research output: Contribution to journalArticlepeer-review

122 Scopus citations

Abstract

Rationale: Research has begun to examine how acute cognitive impairment from alcohol could contribute to alcohol abuse. Specifically, alcohol-induced impairment of inhibitory control could compromise the drinker's ability to stop the self-administration of alcohol, increasing the risk of binge drinking. Objective: The present study was designed to test this hypothesis by examining the relation between acute alcohol impairment of inhibitory control and alcohol consumption during a single drinking episode. Materials and methods: Twenty-six healthy adults performed a cued go/no-go task that measured inhibitory control. The study tested the degree to which their inhibitory control was impaired by a moderate dose of alcohol (0.65 g/kg) versus a placebo and the extent to which individual differences in this impairment predicted levels of alcohol consumption as assessed by ad lib drinking in the laboratory. Results: In accord with the hypothesis, greater impairment of inhibitory control from alcohol was associated with increased ad lib consumption. Conclusion: Acute impairment of inhibitory control might be an important cognitive effect that contributes to abuse in addition to the positive rewarding effects of the drug.

Original languageEnglish
Pages (from-to)315-324
Number of pages10
JournalPsychopharmacology
Volume201
Issue number3
DOIs
StatePublished - Dec 2008

Bibliographical note

Funding Information:
Acknowledgement This research was supported by grant R21 DA021027 from the National Institute on Drug Abuse and by grant R01 AA12895 from the National Institute on Alcohol Abuse and Alcoholism.

Keywords

  • Abuse potential
  • Ad lib consumption
  • Alcohol
  • Cued go/no-go task
  • Inhibition
  • Neurocognitive mechanisms

ASJC Scopus subject areas

  • Pharmacology

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