Individual differences in novelty seeking on the playground maze predict amphetamine conditioned place preference

J. E. Klebaur, M. T. Bardo

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


Previous research has shown that a rat's level of activity in a novel environment can predict the strength of amphetamine-induced locomotor behavior and self-administration, but not amphetamine-conditioned place preference. The increase in activity observed when a rat is exposed to an inescapable novel environment may reflect escape behavior due to stress. To assess approach to novelty in a free-choice test, we examined the ability of a new test, the playground maze, to predict individual differences in response to amphetamine (1 or 3 mg/kg). Using the playground maze to categorize rats as either high or low novelty seekers, it was found that individual differences in novelty seeking did not predict amphetamine-induced changes in locomotor activity following either a single or repeated injections. However, high novelty seekers showed greater amphetamine-conditioned place preference than low novelty seekers. These results provide support for the hypothesis that novelty seeking and drug reward are neuropharmacologically related. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalPharmacology Biochemistry and Behavior
Issue number1
StatePublished - May 1999

Bibliographical note

Funding Information:
The authors would like to thank Patrick Abner for his help on this project. This research was supported by USPHS Grant DA05312 to M. T. Bardo. J. E. Klebaur was supported by a Kentucky Research Challenge Trust Fellowship while preparing this report for publication.


  • Amphetamine
  • Conditioned place preference
  • Individual differences
  • Locomotor activity
  • Novelty seeking

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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