Abstract
Previous research has shown a relationship between impulsive personality and the subjective and reinforcing effects of d-amphetamine. Impulsive personality, however, is comprised of multiple dimensions. The association between different dimensions of impulsive personality and the subjective and reinforcing effects of d-amphetamine is unknown. The objective of this study was to assess the independent contributions of the "sensation-seeking" and "impulsivity" dimensions of the impulsive sensation-seeking subscale of the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ) to the subjective and reinforcing effects of d-amphetamine. Forty healthy emerging adults varying in scores on the sensation-seeking and impulsivity dimensions of the ZKPQ participated in a double-blind, placebocontrolled, randomized study comprised of 4 2-day blocks. Each 2-day block consisted of a sample day and self-administration day. Subjective effects and physiological measurements were taken prior to, and hourly for 3 hr following, dose administration. On sample days participants were given 8 capsules containing 0, 1, or 2 mg d-amphetamine. On self-administration days participants were able to earn capsules containing the same dose of d-amphetamine that was administered on the previous sample day by responding on a Modified Progressive Ratio Task. The "sensation-seeking" dimension was positively associated with drug taking on the Modified Progressive Ratio Task, subjective effects (e.g., "good effect"), and heart rate. However, no clear relationship between the "impulsivity" dimension and outcome measures was observed. In conclusion, these data suggest that the narrow sensation-seeking dimension of impulsive sensation-seeking is associated with initial drug liking and drug taking behavior and may be a key predictor of drug use initiation.
| Original language | English |
|---|---|
| Pages (from-to) | 436-446 |
| Number of pages | 11 |
| Journal | Experimental and Clinical Psychopharmacology |
| Volume | 24 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 2016 |
Bibliographical note
Publisher Copyright:© 2016 American Psychological Association.
Funding
Preliminary reports of the data in this article have been presented at the 2012 and 2014 annual meetings of the College on Problems of Drug Dependence and the 2012 annual meeting of the Society for Neuroscience. Joshua Lile and Thomas H. Kelly contributed to the design, analysis, and data collection for this study. Richard Kryscio contributed to the analysis of these data. Catherine Martin contributed to data collection for this study. Arit Harvanko contributed to the analysis and first draft of this study. All authors contributed to the preparation of this article and have read and approved the final manuscript. Mr. Glenn Robbins and Ms. Cleeve Emurian are thanked for their assistance in data collection for this study. This research was supported by NIH Grants P50 DA05312, UL1TR000117, and K02 DA031766. These funding sources had no role other than financial support.
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | UL1TR000117, K02 DA031766 |
| National Institute on Drug Abuse | P50DA005312 |
| Society for Neuroscience |
Keywords
- Reinforcement
- Self-administration
- Sensation-seeking
- Subjective effects
ASJC Scopus subject areas
- Pharmacology
- Psychiatry and Mental health
- Pharmacology (medical)
