Indocyanine green loaded SPIO nanoparticles with phospholipid-PEG coating for dual-modal imaging and photothermal therapy

Yan Ma, Sheng Tong, Gang Bao, Chuang Gao, Zhifei Dai

Research output: Contribution to journalArticlepeer-review

218 Scopus citations

Abstract

A biodegradable nanotheranostic agent has been successfully constructed for fluorescence/magnetic resonance dual-modal imaging guided photothermal therapy by loading indocyanine green (ICG) molecules into 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethylene glycol)] (DSPE-PEG) coated superparamagnetic iron oxide (SPIO) nanoparticles (NPs). It was proved that the obtained SPIO

Original languageEnglish
Pages (from-to)7706-7714
Number of pages9
JournalBiomaterials
Volume34
Issue number31
DOIs
StatePublished - Oct 2013

Bibliographical note

Funding Information:
This research was financially supported by National Natural Science Foundation for Distinguished Young Scholars (No. 81225011 to ZD), State Key Program of National Natural Science of China (Grant No. 81230036 to ZD), and the National Heart Lung and Blood Institute of the NIH as a Program of Excellence in Nanotechnology ( HHSN268201000043C to GB).

Keywords

  • Fluorescence imaging
  • Indocyanine green
  • MRI
  • Photothermal therapy
  • SPIO nanoparticles

ASJC Scopus subject areas

  • Mechanics of Materials
  • Ceramics and Composites
  • Bioengineering
  • Biophysics
  • Biomaterials

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