Induced morphological changes in human small cell lung carcinoma cells

R. C. McGarry; V. Feyles; A. Tuff; J. Chapman; L. M. Jerry

doi:10.1016/0304-3835(91)90078-V

Induced morphological changes in human small cell lung carcinoma cells

R. C. McGarry, V. Feyles, A. Tuff, J. Chapman, L. M. Jerry

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Several theories suggest that lung carcinomas are not totally separate entities, but are derived from a common precursor, probably of endodermal origin [1,2]. The histological classification of lung cancers is complex, with much overlap between groups broadly designated as small cell (SCLC), squamous cell, adenocarcinoma and all others simply termed non-small cell. It is shown here that in vitro exposure of classic, non-adherent SCLC lines to 10 μM 5′ bromodeoxyuridine (BrdU) results in a rapid cell-line dependent change to a morphology consistent with an adherent, non-small cell phenotype. Accompanying this morphological shift is a decreased expression of the amplified N-myc protooncogene. These induced changes underline the morphological relatedness of lung carcinoma cell lines.

Original language	English
Pages (from-to)	67-74
Number of pages	8
Journal	Cancer Letters
Volume	61
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(91)90078-V
State	Published - Dec 9 1991

Funding

We would like to thank Mary Ilkiw and Laurie Bryant for assistance with the flow cytometry. Supported by the National Cancer Institute of Canada by grants to R. McGarry and L.M. Jerry. V. Feyles is a fellow of the Alberta Cancer Board.

Funders	Funder number
National Cancer Institute of Canada

Keywords

5′-bromodeoxyuridine
differentiation
lung carcinomna
N-myc

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0304-3835(91)90078-V

Cite this

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AU - Feyles, V.

AU - Tuff, A.

AU - Chapman, J.

AU - Jerry, L. M.

PY - 1991/12/9

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Induced morphological changes in human small cell lung carcinoma cells

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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