Induction of PGH synthase and c-fos mRNA during early reperfusion of ischemic rat brain

Mary L. Holtz, Mark S. Kindy, Susan Craddock, Robert W. Moore, L. Creed Pettigrew

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


We examined the effect of reversible ischemia on the transcription of prostaglandin endoperoxide synthase (PGHS-1) and c-fos mRNA in rat cerebral cortex. The level of PGHS-1 mRNA climaxed after 30 min of ischemia whereas transcription of c-fos mRNA peaked after 60 min of postischemic reperfusion. We conclude that cerebral ischemia causes early transcription of PGHS-1, without modulation by the c-fos gene or its translated product.

Original languageEnglish
Pages (from-to)339-343
Number of pages5
JournalMolecular Brain Research
Issue number1-2
StatePublished - Jan 1996

Bibliographical note

Funding Information:
This work was presenteda s an abstractb eforethe 24th Annual Meeting of the Society for Neuroscienceh eld in Miami Beach, Florida, on 13-18 November 1994. Financial supportw as providedb y a grant from the Council for Tobacco Research (M.S.K.), NIH AG09690 (M.S.K.), NIH/NINDS NS33773a nd Clinical InvestigatorD evelop-ment Award NS01505 (L.C.P.), a grant-in-aid from the Kentucky Affiliate of the American Heart Association (LC.P. and M.S.K.), and a Merit Review grant from the Researcha nd DevelopmenOt ffice, Medical ResearchS er-vice, Departmenot f VeteransA ffairs (L.C.P.).


  • Brain
  • C-fos
  • Cerebral ischemia
  • Cyclooxygenase
  • Prostaglandin endoperoxide synthase
  • mRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience


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