Induction of PGH synthase and c-fos mRNA during early reperfusion of ischemic rat brain

Mary L. Holtz; Mark S. Kindy; Susan Craddock; Robert W. Moore; L. Creed Pettigrew

doi:10.1016/0169-328X(95)00212-B

Induction of PGH synthase and c-fos mRNA during early reperfusion of ischemic rat brain

Mary L. Holtz, Mark S. Kindy, Susan Craddock, Robert W. Moore, L. Creed Pettigrew

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We examined the effect of reversible ischemia on the transcription of prostaglandin endoperoxide synthase (PGHS-1) and c-fos mRNA in rat cerebral cortex. The level of PGHS-1 mRNA climaxed after 30 min of ischemia whereas transcription of c-fos mRNA peaked after 60 min of postischemic reperfusion. We conclude that cerebral ischemia causes early transcription of PGHS-1, without modulation by the c-fos gene or its translated product.

Original language	English
Pages (from-to)	339-343
Number of pages	5
Journal	Molecular Brain Research
Volume	35
Issue number	1-2
DOIs	https://doi.org/10.1016/0169-328X(95)00212-B
State	Published - Jan 1996

Bibliographical note

Funding Information:
This work was presenteda s an abstractb eforethe 24th Annual Meeting of the Society for Neuroscienceh eld in Miami Beach, Florida, on 13-18 November 1994. Financial supportw as providedb y a grant from the Council for Tobacco Research (M.S.K.), NIH AG09690 (M.S.K.), NIH/NINDS NS33773a nd Clinical InvestigatorD evelop-ment Award NS01505 (L.C.P.), a grant-in-aid from the Kentucky Affiliate of the American Heart Association (LC.P. and M.S.K.), and a Merit Review grant from the Researcha nd DevelopmenOt ffice, Medical ResearchS er-vice, Departmenot f VeteransA ffairs (L.C.P.).

Keywords

Brain
C-fos
Cerebral ischemia
Cyclooxygenase
Prostaglandin endoperoxide synthase
mRNA

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/0169-328X(95)00212-B

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title = "Induction of PGH synthase and c-fos mRNA during early reperfusion of ischemic rat brain",

abstract = "We examined the effect of reversible ischemia on the transcription of prostaglandin endoperoxide synthase (PGHS-1) and c-fos mRNA in rat cerebral cortex. The level of PGHS-1 mRNA climaxed after 30 min of ischemia whereas transcription of c-fos mRNA peaked after 60 min of postischemic reperfusion. We conclude that cerebral ischemia causes early transcription of PGHS-1, without modulation by the c-fos gene or its translated product.",

keywords = "Brain, C-fos, Cerebral ischemia, Cyclooxygenase, Prostaglandin endoperoxide synthase, mRNA",

author = "Holtz, {Mary L.} and Kindy, {Mark S.} and Susan Craddock and Moore, {Robert W.} and Pettigrew, {L. Creed}",

note = "Funding Information: This work was presenteda s an abstractb eforethe 24th Annual Meeting of the Society for Neuroscienceh eld in Miami Beach, Florida, on 13-18 November 1994. Financial supportw as providedb y a grant from the Council for Tobacco Research (M.S.K.), NIH AG09690 (M.S.K.), NIH/NINDS NS33773a nd Clinical InvestigatorD evelop-ment Award NS01505 (L.C.P.), a grant-in-aid from the Kentucky Affiliate of the American Heart Association (LC.P. and M.S.K.), and a Merit Review grant from the Researcha nd DevelopmenOt ffice, Medical ResearchS er-vice, Departmenot f VeteransA ffairs (L.C.P.).",

year = "1996",

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doi = "10.1016/0169-328X(95)00212-B",

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T1 - Induction of PGH synthase and c-fos mRNA during early reperfusion of ischemic rat brain

AU - Holtz, Mary L.

AU - Kindy, Mark S.

AU - Craddock, Susan

AU - Moore, Robert W.

AU - Pettigrew, L. Creed

N1 - Funding Information: This work was presenteda s an abstractb eforethe 24th Annual Meeting of the Society for Neuroscienceh eld in Miami Beach, Florida, on 13-18 November 1994. Financial supportw as providedb y a grant from the Council for Tobacco Research (M.S.K.), NIH AG09690 (M.S.K.), NIH/NINDS NS33773a nd Clinical InvestigatorD evelop-ment Award NS01505 (L.C.P.), a grant-in-aid from the Kentucky Affiliate of the American Heart Association (LC.P. and M.S.K.), and a Merit Review grant from the Researcha nd DevelopmenOt ffice, Medical ResearchS er-vice, Departmenot f VeteransA ffairs (L.C.P.).

PY - 1996/1

Y1 - 1996/1

N2 - We examined the effect of reversible ischemia on the transcription of prostaglandin endoperoxide synthase (PGHS-1) and c-fos mRNA in rat cerebral cortex. The level of PGHS-1 mRNA climaxed after 30 min of ischemia whereas transcription of c-fos mRNA peaked after 60 min of postischemic reperfusion. We conclude that cerebral ischemia causes early transcription of PGHS-1, without modulation by the c-fos gene or its translated product.

AB - We examined the effect of reversible ischemia on the transcription of prostaglandin endoperoxide synthase (PGHS-1) and c-fos mRNA in rat cerebral cortex. The level of PGHS-1 mRNA climaxed after 30 min of ischemia whereas transcription of c-fos mRNA peaked after 60 min of postischemic reperfusion. We conclude that cerebral ischemia causes early transcription of PGHS-1, without modulation by the c-fos gene or its translated product.

KW - Brain

KW - C-fos

KW - Cerebral ischemia

KW - Cyclooxygenase

KW - Prostaglandin endoperoxide synthase

KW - mRNA

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JO - Molecular Brain Research

JF - Molecular Brain Research

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Induction of PGH synthase and c-fos mRNA during early reperfusion of ischemic rat brain

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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