Induction of presenilins in the rat brain after middle cerebral arterial occlusion

Keith R. Pennypacker, Herman Hernandez, Stanley Benkovic, David G. Morgan, Alison E. Willing, Paul R. Sanberg

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

In the present study, we have examined the expression of both presenilins in the rat hippocampus, cortex, striatum, and cerebellum after middle cerebral artery occlusion (MCA-O), an animal model of ischemia. The cortex showed the greatest increase in PS mRNA levels (7-10-fold) at 4 and 8 days posttreatment. Presenilin-1 (PS-1) levels in the contralateral cortex were significantly increased 1 day after MCA-O. In comparison, PS mRNA content was only modestly elevated in the hippocampus and striatum at 4 and 8 days after MCA-O (30100% changes). Other Alzheimer's disease (AD)-related genes, amyloid precursor protein and apolipoprotein E, are induced in brain injury suggesting that these AD-related genes may well be components of a brain-injury response. Thus, a breakdown in this response via cerebrovascular disease and/or genetic mutation may contribute to AD pathology.

Original languageEnglish
Pages (from-to)539-543
Number of pages5
JournalBrain Research Bulletin
Volume48
Issue number5
DOIs
StatePublished - Mar 15 1999

Keywords

  • Alzheimer's disease
  • Gene expression
  • Ischemia
  • Neurodegeneration
  • Stroke

ASJC Scopus subject areas

  • General Neuroscience

Fingerprint

Dive into the research topics of 'Induction of presenilins in the rat brain after middle cerebral arterial occlusion'. Together they form a unique fingerprint.

Cite this