TY - JOUR
T1 - Induction of presenilins in the rat brain after middle cerebral arterial occlusion
AU - Pennypacker, Keith R.
AU - Hernandez, Herman
AU - Benkovic, Stanley
AU - Morgan, David G.
AU - Willing, Alison E.
AU - Sanberg, Paul R.
PY - 1999/3/15
Y1 - 1999/3/15
N2 - In the present study, we have examined the expression of both presenilins in the rat hippocampus, cortex, striatum, and cerebellum after middle cerebral artery occlusion (MCA-O), an animal model of ischemia. The cortex showed the greatest increase in PS mRNA levels (7-10-fold) at 4 and 8 days posttreatment. Presenilin-1 (PS-1) levels in the contralateral cortex were significantly increased 1 day after MCA-O. In comparison, PS mRNA content was only modestly elevated in the hippocampus and striatum at 4 and 8 days after MCA-O (30100% changes). Other Alzheimer's disease (AD)-related genes, amyloid precursor protein and apolipoprotein E, are induced in brain injury suggesting that these AD-related genes may well be components of a brain-injury response. Thus, a breakdown in this response via cerebrovascular disease and/or genetic mutation may contribute to AD pathology.
AB - In the present study, we have examined the expression of both presenilins in the rat hippocampus, cortex, striatum, and cerebellum after middle cerebral artery occlusion (MCA-O), an animal model of ischemia. The cortex showed the greatest increase in PS mRNA levels (7-10-fold) at 4 and 8 days posttreatment. Presenilin-1 (PS-1) levels in the contralateral cortex were significantly increased 1 day after MCA-O. In comparison, PS mRNA content was only modestly elevated in the hippocampus and striatum at 4 and 8 days after MCA-O (30100% changes). Other Alzheimer's disease (AD)-related genes, amyloid precursor protein and apolipoprotein E, are induced in brain injury suggesting that these AD-related genes may well be components of a brain-injury response. Thus, a breakdown in this response via cerebrovascular disease and/or genetic mutation may contribute to AD pathology.
KW - Alzheimer's disease
KW - Gene expression
KW - Ischemia
KW - Neurodegeneration
KW - Stroke
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U2 - 10.1016/S0361-9230(99)00031-3
DO - 10.1016/S0361-9230(99)00031-3
M3 - Article
C2 - 10372515
AN - SCOPUS:0033559257
VL - 48
SP - 539
EP - 543
IS - 5
ER -