Induction of presenilins in the rat brain after middle cerebral arterial occlusion

Keith R. Pennypacker, Herman Hernandez, Stanley Benkovic, David G. Morgan, Alison E. Willing, Paul R. Sanberg

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


In the present study, we have examined the expression of both presenilins in the rat hippocampus, cortex, striatum, and cerebellum after middle cerebral artery occlusion (MCA-O), an animal model of ischemia. The cortex showed the greatest increase in PS mRNA levels (7-10-fold) at 4 and 8 days posttreatment. Presenilin-1 (PS-1) levels in the contralateral cortex were significantly increased 1 day after MCA-O. In comparison, PS mRNA content was only modestly elevated in the hippocampus and striatum at 4 and 8 days after MCA-O (30100% changes). Other Alzheimer's disease (AD)-related genes, amyloid precursor protein and apolipoprotein E, are induced in brain injury suggesting that these AD-related genes may well be components of a brain-injury response. Thus, a breakdown in this response via cerebrovascular disease and/or genetic mutation may contribute to AD pathology.

Original languageEnglish
Pages (from-to)539-543
Number of pages5
JournalBrain Research Bulletin
Issue number5
StatePublished - Mar 15 1999


  • Alzheimer's disease
  • Gene expression
  • Ischemia
  • Neurodegeneration
  • Stroke

ASJC Scopus subject areas

  • General Neuroscience


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