Infection scintigraphy: Added value of single-photon emission computed tomography/computed tomography fusion compared with traditional analysis

Christian J. Ingui, Nirav P. Shah, Mary E. Oates

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

PURPOSE: Positron emission tomography (PET)/computed tomography (CT) imaging is a powerful dual-modality integrating physiology and anatomy. Analogously, fusing separate single-photon emission computed tomography (SPECT) and CT images can overcome interpretive challenges in characterizing and localizing abnormalities. This study explores the value of SPECT/CT image fusion compared with traditional "side-by-side" SPECT-CT image review for infectious /inflammatory processes. METHODS AND MATERIALS: We identified 17 abnormal infection/inflammation SPECT scans in 16 patients (11 indium 111 WBC and 6 gallium citrate Ga 67) with a contemporary CT scan. The SPECT and CT images were uploaded onto "side-by-side" workstations, one with fusion software. Two nuclear radiologists reviewed "side-by-side" SPECT and CT images and fused SPECT/CT images. They scored 2 parameters (anatomical localization and diagnostic confidence) using a 4-point scale (1 "not helpful" to 4 "very helpful"). Score differences more than 1 indicated "added value" and less than 0, "no added value". RESULTS: Compared with "side-by-side" SPECT-CT, fused SPECT/CT images yielded "added value" for anatomical localization in 65%, diagnostic confidence in 71%, and altered interpretations in 47% of cases. Greater confidence was achieved in 75% of cases with altered interpretations and 55% of unaltered cases. CONCLUSIONS: The SPECT/CT image fusion outperformed "side-by-side" SPECT/CT review for anatomical localization and diagnostic confidence of infectious/inflammatory abnormalities. Therefore, SPECT/CT fusion potentially influences clinical decisions and treatment options.

Original languageEnglish
Pages (from-to)375-380
Number of pages6
JournalJournal of Computer Assisted Tomography
Volume31
Issue number3
DOIs
StatePublished - May 2007

Keywords

  • Computed tomography
  • Fusion
  • Infection
  • Inflammatory
  • SPECT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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