Infectious complications associated with the use of acellular dermal matrix in implant-based bilateral breast reconstruction

Joseph L. Hill, Lesley Wong, Pamela Kemper, Jason Buseman, Daniel L. Davenport, Henry C. Vasconez

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Background: The use of acellular dermal matrix (ADM) has become a routine practice in implant-based breast reconstruction. Bilateral mastectomy is becoming more popular in cases of unilateral breast cancer. ADM has been associated with an increased incidence of complications. Methods: We identified cases of bilateral implant-based breast reconstruction over a 5-year period. Data collection included medical comorbities, details of operative management, and details of postoperative cancer treatment. Results: On univariate analysis, the use of ADM (31% vs. 7%, P = 0.018), smoking (37% vs. 13%, P = 0.045), and open wound (55% vs. 13%, P = 0.006) were significantly associated with increased risk of infection. Multivariate analysis revealed open wound as the strongest predictor of infection. Conclusions: The use of ADM is associated with an increased risk of infection in bilateral implant-based breast reconstruction. However, it does not appear to be an independent risk factor by itself.

Original languageEnglish
Pages (from-to)432-434
Number of pages3
JournalAnnals of Plastic Surgery
Volume68
Issue number5
DOIs
StatePublished - May 2012

Keywords

  • acellular dermal matrix
  • bilateral implant-based breast reconstruction

ASJC Scopus subject areas

  • Surgery

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