Inflammation: A driving force speeds cancer metastasis

Research output: Contribution to journalReview articlepeer-review

285 Scopus citations

Abstract

It has been increasingly recognized that tumor microenvironment plays an important role in carcinogenesis. Inflammatory component is present and contributes to tumor proliferation, angiogenesis, metastasis and resistance to hormonal and chemotherapy. This review highlights the role of inflammation in the tumor metastasis. We focus on the function of proinflammatory factors, particularly cytokines during tumor metastasis. Understanding of the mechanisms by which inflammation contributes to metastasis will lead to innovative approach for treating cancer.

Original languageEnglish
Pages (from-to)3267-3273
Number of pages7
JournalCell Cycle
Volume8
Issue number20
DOIs
StatePublished - Oct 15 2009

Keywords

  • Epithelial-mesenchymal transition
  • Inflammation
  • Metastasis

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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