TY - JOUR
T1 - Inflammation and cardiometabolic diseases induced by persistent organic pollutants and nutritional interventions
T2 - Effects of multi-organ interactions
AU - Wang, Zhongmin
AU - Zhou, Yixuan
AU - Xiao, Xia
AU - Liu, Aowen
AU - Wang, Shengnan
AU - Preston, Roger J.S.
AU - Zaytseva, Yekaterina Y.
AU - He, Guangzhao
AU - Xiao, Wenjin
AU - Hennig, Bernhard
AU - Deng, Pan
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/12/15
Y1 - 2023/12/15
N2 - The development and outcome of inflammatory diseases are associated with genetic and lifestyle factors, which include chemical and nonchemical stressors. Persistent organic pollutants (POPs) are major groups of chemical stressors. For example, dioxin-like polychlorinated biphenyls (PCBs), per- and polyfluoroalkyl substances (PFASs), and polybrominated diphenyl ethers (PBDEs) are closely associated with the incidence of inflammatory diseases. The pathology of environmental chemical-mediated inflammatory diseases is complex and may involve disturbances in multiple organs, including the gut, liver, brain, vascular tissues, and immune systems. Recent studies suggested that diet-derived nutrients (e.g., phytochemicals, vitamins, unsaturated fatty acids, dietary fibers) could modulate environmental insults and affect disease development, progression, and outcome. In this article, mechanisms of environmental pollutant-induced inflammation and cardiometabolic diseases are reviewed, focusing on multi-organ interplays and highlighting recent advances in nutritional strategies to improve the outcome of cardiometabolic diseases associated with environmental exposures. In addition, advanced system biology approaches are discussed, which present unique opportunities to unveil the complex interactions among multiple organs and to fuel the development of precision intervention strategies in exposed individuals.
AB - The development and outcome of inflammatory diseases are associated with genetic and lifestyle factors, which include chemical and nonchemical stressors. Persistent organic pollutants (POPs) are major groups of chemical stressors. For example, dioxin-like polychlorinated biphenyls (PCBs), per- and polyfluoroalkyl substances (PFASs), and polybrominated diphenyl ethers (PBDEs) are closely associated with the incidence of inflammatory diseases. The pathology of environmental chemical-mediated inflammatory diseases is complex and may involve disturbances in multiple organs, including the gut, liver, brain, vascular tissues, and immune systems. Recent studies suggested that diet-derived nutrients (e.g., phytochemicals, vitamins, unsaturated fatty acids, dietary fibers) could modulate environmental insults and affect disease development, progression, and outcome. In this article, mechanisms of environmental pollutant-induced inflammation and cardiometabolic diseases are reviewed, focusing on multi-organ interplays and highlighting recent advances in nutritional strategies to improve the outcome of cardiometabolic diseases associated with environmental exposures. In addition, advanced system biology approaches are discussed, which present unique opportunities to unveil the complex interactions among multiple organs and to fuel the development of precision intervention strategies in exposed individuals.
KW - Intervention
KW - Multi-organ
KW - PBDE
KW - PCB
KW - PFAS
KW - Persistent organic pollutants
KW - Toxicity
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U2 - 10.1016/j.envpol.2023.122756
DO - 10.1016/j.envpol.2023.122756
M3 - Review article
C2 - 37844865
AN - SCOPUS:85174342908
SN - 0269-7491
VL - 339
JO - Environmental Pollution
JF - Environmental Pollution
M1 - 122756
ER -