Inflammation fuels tumor progress and metastasis

Jingyi Liu, Pengnian Charles Lin, Binhua P. Zhou

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Inflammation is a beneficial response that can remove pathogens, repair injured tissue and restore homeostasis to damaged tissues and organs. However, increasing evidence indicate that chronic inflammation plays a pivotal role in tumor development, as well as progression, metastasis, and resistance to chemotherapy. We will review the current knowledge regarding the contribution of inflammation to epithelial mesenchymal transition. We will also provide some perspectives on the relationship between ER-stress signals and metabolism, and the role of these processes in the development of inflammation.

Original languageEnglish
Pages (from-to)3032-3040
Number of pages9
JournalCurrent Pharmaceutical Design
Volume21
Issue number21
DOIs
StatePublished - Jun 1 2015

Bibliographical note

Publisher Copyright:
© 2015 Bentham Science Publishers.

Keywords

  • Epithelial-mesenchymal transition
  • Inflammation
  • Metastasis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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