Inflammation fuels tumor progress and metastasis

Jingyi Liu; Pengnian Charles Lin; Binhua P. Zhou

doi:10.2174/1381612821666150514105741

Inflammation fuels tumor progress and metastasis

Jingyi Liu
, Pengnian Charles Lin
, Binhua P. Zhou

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Inflammation is a beneficial response that can remove pathogens, repair injured tissue and restore homeostasis to damaged tissues and organs. However, increasing evidence indicate that chronic inflammation plays a pivotal role in tumor development, as well as progression, metastasis, and resistance to chemotherapy. We will review the current knowledge regarding the contribution of inflammation to epithelial mesenchymal transition. We will also provide some perspectives on the relationship between ER-stress signals and metabolism, and the role of these processes in the development of inflammation.

Original language	English
Pages (from-to)	3032-3040
Number of pages	9
Journal	Current Pharmaceutical Design
Volume	21
Issue number	21
DOIs	https://doi.org/10.2174/1381612821666150514105741
State	Published - Jun 1 2015

Bibliographical note

Publisher Copyright:
© 2015 Bentham Science Publishers.

Funding

Funders	Funder number
National Institutes of Health (NIH)	RO1s CA125454 and CA188118, RO1s CA125454
National Childhood Cancer Registry – National Cancer Institute	R01CA188118

Keywords

Epithelial-mesenchymal transition
Inflammation
Metastasis

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.2174/1381612821666150514105741

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title = "Inflammation fuels tumor progress and metastasis",

abstract = "Inflammation is a beneficial response that can remove pathogens, repair injured tissue and restore homeostasis to damaged tissues and organs. However, increasing evidence indicate that chronic inflammation plays a pivotal role in tumor development, as well as progression, metastasis, and resistance to chemotherapy. We will review the current knowledge regarding the contribution of inflammation to epithelial mesenchymal transition. We will also provide some perspectives on the relationship between ER-stress signals and metabolism, and the role of these processes in the development of inflammation.",

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AU - Zhou, Binhua P.

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N2 - Inflammation is a beneficial response that can remove pathogens, repair injured tissue and restore homeostasis to damaged tissues and organs. However, increasing evidence indicate that chronic inflammation plays a pivotal role in tumor development, as well as progression, metastasis, and resistance to chemotherapy. We will review the current knowledge regarding the contribution of inflammation to epithelial mesenchymal transition. We will also provide some perspectives on the relationship between ER-stress signals and metabolism, and the role of these processes in the development of inflammation.

AB - Inflammation is a beneficial response that can remove pathogens, repair injured tissue and restore homeostasis to damaged tissues and organs. However, increasing evidence indicate that chronic inflammation plays a pivotal role in tumor development, as well as progression, metastasis, and resistance to chemotherapy. We will review the current knowledge regarding the contribution of inflammation to epithelial mesenchymal transition. We will also provide some perspectives on the relationship between ER-stress signals and metabolism, and the role of these processes in the development of inflammation.

KW - Epithelial-mesenchymal transition

KW - Inflammation

KW - Metastasis

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Inflammation fuels tumor progress and metastasis

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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