TY - JOUR
T1 - Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia
AU - Avison, Malcolm J.
AU - Nath, Avindra
AU - Greene-Avison, Robin
AU - Schmitt, Frederick A.
AU - Bales, Rodney A.
AU - Ethisham, As'ad
AU - Greenberg, Richard N.
AU - Berger, Joseph R.
PY - 2004/8
Y1 - 2004/8
N2 - Increased postcontrast enhancement in contrast-enhanced magnetic resonance imaging (CE-MRI) of the central nervous system (CNS) is a predictor of human immunodeficiency virus (HIV) dementia severity in HIV-infected subjects. The present study confirms this earlier finding in a mildly impaired patient cohort, and demonstrates that the increased postcontrast enhancement is correlated with increased cerebrospinal fluid (CSF) levels of monocyte chemoattractant protein (MCP)-1, an inflammatory chemokine, and increased CNS levels of mI, a microglial marker. These results suggest that early CNS inflammation may underlie the microvascular changes observed, and may be a factor in the development of HIV dementia.
AB - Increased postcontrast enhancement in contrast-enhanced magnetic resonance imaging (CE-MRI) of the central nervous system (CNS) is a predictor of human immunodeficiency virus (HIV) dementia severity in HIV-infected subjects. The present study confirms this earlier finding in a mildly impaired patient cohort, and demonstrates that the increased postcontrast enhancement is correlated with increased cerebrospinal fluid (CSF) levels of monocyte chemoattractant protein (MCP)-1, an inflammatory chemokine, and increased CNS levels of mI, a microglial marker. These results suggest that early CNS inflammation may underlie the microvascular changes observed, and may be a factor in the development of HIV dementia.
KW - AIDS
KW - Blood-brain barrier (BBB)
KW - CNS
KW - HIV dementia
KW - Inflammation
KW - Magnetic resonance
KW - Magnetic resonance imaging (MRI)
KW - Magnetic resonance spectroscopy (MRS)
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U2 - 10.1080/13550280490463532
DO - 10.1080/13550280490463532
M3 - Article
C2 - 15371152
AN - SCOPUS:4344692314
SN - 1355-0284
VL - 10
SP - 223
EP - 232
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
IS - 4
ER -